Effects of chronic hypoxia on the secretory responses of rat salivary glands

Archives of Oral Biology
J C ElverdinM J Giglio

Abstract

Female Wistar rats were placed for 3 weeks in a simulated chamber evacuated by a vacuum pump and maintained at 40.5 kPa (7100 m). Dose-response curves were obtained through the sequential injection, via the femoral vein, of increasing doses of methacholine, methoxamine, isoprenaline and substance P. The secretory activity in the parotid gland after exposure to chronic hypoxia was significantly decreased for all agonists studied, and the submaxillary gland showed the same behaviour except in relation to isoprenaline, which did not show a significant difference compared to controls. These data suggest that changes in the number or sensitivity of autonomic receptors and/or alterations in the intracellular signals caused by hypoxia may be involved in the reduction in salivary secretory responses.

References

Apr 1, 1988·International Journal of Sports Medicine·J P RichaletF Lhoste
Mar 1, 1974·Clinical Science and Molecular Medicine·C HunterE J Clegg

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Citations

Jul 28, 2001·Autonomic Neuroscience : Basic & Clinical·M I VacasM A Luchelli
Nov 18, 2000·Plastic and Reconstructive Surgery·J H SpiegelH J Buncke
Oct 30, 2016·Archives of Oral Biology·Antonela R TerrizziMaría Pilar Martínez
Mar 24, 1998·The Journal of Laryngology and Otology·L P MilesJ Reddy
Sep 3, 2020·Expert Review of Proteomics·Paloma Menéndez-ValladaresJoan Montaner

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