Effects of chronic L-NAME on nitrotyrosine expression and renal vascular reactivity in rats with chronic bile-duct ligation

Clinical Science
Antonia AlcarazM C Ortíz

Abstract

In liver cirrhosis, elevated levels of NO and ROS (reactive oxygen species) might greatly favour the generation of peroxynitrite. Peroxynitrite is a highly reactive oxidant and it can potentially alter the vascular reactivity and the function of different organs. In the present study, we evaluated whether peroxynitrite levels are related to the progression of renal vascular and excretory dysfunction during experimental cirrhosis induced by chronic BDL (bile-duct ligation) in rats. Experiments were performed at 7, 15 and 21 days after BDL in rats and in rats 21 days post-BDL chronically treated with L-NAME (N(G)-nitro-L-arginine methyl ester). Sodium balance, BP (blood pressure), basal RPP (renal perfusion pressure) and the renal vascular response to PHE (phenylephrine) and ACh (acetylcholine) in isolated perfused kidneys were measured. NO levels were calculated as 24-h urinary excretion of nitrites, ROS as TBARS (thiobarbituric acid-reacting substances), and peroxynitrite formation as the renal expression of nitrotyrosine. BDL rats had progressive sodium retention, and decreased BP, RPP and renal vascular responses to PHE and ACh in the time following BDL. They also had increasing levels of NO and ROS, and renal nitrotyrosine a...Continue Reading

References

Jan 1, 1995·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·M P PanozzoM Plebani
Aug 1, 1993·Clinical Science·N M AtucháJ Garcia-Estañ
Nov 1, 1996·The American Journal of Physiology·J S Beckman, W H Koppenol
Dec 1, 1996·Journal of the American Society of Nephrology : JASN·M C OrtízJ García-Estañ
Jul 1, 1997·The British Journal of Surgery·M InanI Sahin-Erdemli
Jan 1, 1997·Pharmacology & Therapeutics·P W Hadoke, P C Hayes
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B FernandoK Moore
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R MarleyK Moore
Feb 26, 2000·Cardiovascular Research·P J Andrew, B Mayer
Aug 17, 2001·European Journal of Gastroenterology & Hepatology·T C SchmandraE W Hanisch
Aug 23, 2001·Pharmacology & Therapeutics·A Bomzon, P Ljubuncic
Sep 15, 2001·Free Radical Biology & Medicine·L H OttesenK Moore
Jan 15, 2002·American Journal of Physiology. Cell Physiology·Christy-Lynn M Cooke, Sandra T Davidge
May 22, 2003·The American Journal of Pathology·Guillermo Fernández-VaroWladimiro Jiménez
Jun 24, 2003·Journal of the American Society of Nephrology : JASN·Motoaki MiyazonoEthan P Carter
Aug 13, 2003·Kidney International·M Clara OrtizLuis A Juncos
Oct 30, 2003·American Journal of Physiology. Renal Physiology·Martin GraebeThomas E N Jonassen
Feb 28, 2004·Experimental Biology and Medicine·Jianfeng LiBurton M Altura
Mar 24, 2004·Chemistry and Physics of Lipids·Kevin Moore
Jan 11, 2005·Current Vascular Pharmacology·Noemí M AtuchaJoaquín García-Estañ
Feb 9, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·M C Islas-CarbajalA R Rincón-Sánchez
Mar 23, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Paolo AngeliWladimiro Jiménez
May 25, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Chang-Li WeiHoon-Eng Khoo
Aug 23, 2005·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Yasumi KatsutaTeruo Takano
Dec 24, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Rima Tahseldar-RoumiehRamzi Sabra
Mar 25, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ali R ManiKevin P Moore
Jul 4, 2006·The Journal of Pharmacology and Experimental Therapeutics·Salvatore CuzzocreaDaniela Salvemini
Dec 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A AlcarazM C Ortiz

❮ Previous
Next ❯

Citations

Aug 18, 2018·Nutrients·María D ParedesJoaquín García-Estañ
Aug 11, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chiao-Lin ChuangShou-Dong Lee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Antonia AlcarazM C Ortíz
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Ayako EndohSumio Watanabe
Hepatology Research : the Official Journal of the Japan Society of Hepatology
O FloresA Esteller
Archivos del Instituto de Cardiología de México
A Sánchez MendozaB A Escalante Acosta
© 2021 Meta ULC. All rights reserved