PMID: 2125080Jan 1, 1990Paper

Effects of chronic lithium treatment on serotonin binding sites in rat brain

Journal of Psychiatric Research
Y OdagakiI Yamashita

Abstract

The effects of lithium treatment on serotonin (5-HT) binding sites in the rat brain were investigated. Oral administration of lithium carbonate for 3 weeks did not influence 5-HT2 binding sites in the cerebral cortex. On the other hand, the number of 5-HT1 binding sites labeled with [3H]5-HT was decreased significantly in the hippocampus, but not in the cerebral cortex. While non-5-HT1A sites, defined as specific [3H]5-HT binding in the presence of 100 nM 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), were not affected by lithium treatment in either brain region, chronic lithium administration reduced significantly the density of 5-HT1A sites labeled with [3H]8-OH-DPAT only in the hippocampus, but not in the cerebral cortex. These results suggest that 5-HT1A components are responsible for lithium-induced down-regulation of 5-HT1 binding sites in the hippocampus and that 5-HT1A sites in the hippocampus might be connected with the therapeutic efficacy of lithium.

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Citations

Jan 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·M E NewmanB Shapira
Mar 23, 2002·European Journal of Pharmacology·Alessandro SerrettiEnrico Smeraldi
Apr 12, 2000·Journal of Psychiatric Research·A SerrettiE Smeraldi
Sep 30, 1999·Journal of Psychiatric Research·A SerrettiE Smeraldi
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Oct 20, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·H GrunzeJ Walden
Mar 27, 2002·The Pharmacogenomics Journal·A SerrettiE Smeraldi
Mar 1, 1994·Journal of the American Academy of Child and Adolescent Psychiatry·N AlessiJ K Zubieta
Jul 7, 1999·Fundamental & Clinical Pharmacology·J P Redrobe, M Bourin
Feb 4, 2003·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Alessandro Serretti, Paola Artioli
Sep 11, 1999·Neurochemistry International·M N SubhashB N Srinivas
Apr 28, 2007·Neuroscience and Biobehavioral Reviews·Michel Bourin, Corina Prica
Dec 14, 2004·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L CarbonellJ Forn
Dec 1, 2003·Acta Neuropsychiatrica·B Corbella, E Vieta
May 7, 2002·American Journal of Medical Genetics·Alessandro SerrettiEnrico Smeraldi
Sep 28, 2002·Journal of Clinical Psychopharmacology·Ana Gonzalez-PintoJ A Micó
Feb 15, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Mala AnanthChuan Huang

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