PMID: 7932038Apr 1, 1994Paper

Effects of chronic melatonin administration on adrenal medulla catecholamine metabolism in adult male golden hamsters

Journal of Pineal Research
A EsquifinoR W Steger

Abstract

The role of melatonin on adrenal medullary function was evaluated in adult golden (Syrian) hamsters injected daily at either 0800 or 1600 with melatonin (25 micrograms/hamster) or vehicle (0.1% ethanol in saline). Sixty days after initiation of treatment and 16 or 24 hr after the last injection of melatonin, animals were killed by decapitation and blood and tissue collected. Plasma prolactin levels were reduced by chronic administration of melatonin only when animals were treated at 1600. Tyrosine hydroxylase (TH) activity in the adrenal medulla was not changed by either morning or afternoon administration of melatonin. Phenylethanolamine-N-methyl transferase (PNMT) was changed by afternoon administration of melatonin. Morning and afternoon melatonin injections led to the reduction of both adrenal monoamine oxidase (MAO) and catechol-O-methyl transferase (COMT) activities although the afternoon injections led to a greater magnitude of change. Norepinephrine and epinephrine contents were significantly reduced by morning melatonin administration but were not changed by afternoon administration of the hormone. These data suggest that melatonin has direct and possibly indirect effects on adrenal medullary function in the hamster. H...Continue Reading

References

Jan 1, 1991·Annual Review of Pharmacology and Toxicology·D N Krause, M L Dubocovich
Jan 1, 1990·Life Sciences·B Stankov, R J Reiter
Jan 1, 1988·Chronobiology International·M A VillanúaA I Esquifino
Jan 1, 1984·Endocrine Reviews·J P Preslock

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Citations

Apr 25, 2015·Journal of Pineal Research·Avnesh S ThakorDino A Giussani
Aug 9, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Bojana StefanovicSladjana Dronjak
Jun 7, 2019·Journal of Cellular Biochemistry·Hamed Jafari-VayghanMohammad Alizadeh
Jul 14, 2020·Frontiers in Neuroscience·Anna Ashton, Aarti Jagannath

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