Abstract
After an acute (4 h) treatment with an irreversible cholinesterase inhibitor organophosphate, metrifonate (100 mg/kg i.p.), the activities of both acetyl- and butyrylcholinesterase were inhibited (66.0-70.7% of the control level) in the rat brain cortex and hippocampus. There were no significant changes in the acetyl- and butyrylcholinesterase activities in the olfactory bulb, or in the choline acetyltransferase activity in all three brain areas. After chronic (2 or 5 week) metrifonate treatment (100 mg/kg daily i.p.), the activities of both cholinesterases were substantially inhibited in the rat brain cortex and hippocampus (15.8-31.8% of the control levels), but there was no inhibition of the choline acetyltransferase activity. Moreover, chronic metrifonate treatment did not have any effect on the distribution of the acetylcholinesterase molecular forms. In vitro, metrifonate proved to be a more potent inhibitor of butyryl- than of acetylcholinesterase in both the cortex and the hippocampus. In the hippocampus, the butyrylcholinesterase activity was twice as sensitive to metrifonate inhibition as that in the cortex (IC50 values 0.22 and 0.46 microM, respectively). The effects of chronic (5 week) metrifonate treatment on the b...Continue Reading
References
May 7, 1976·Analytical Biochemistry·M M Bradford
Feb 1, 1975·Journal of Neurochemistry·F Fonnum
Jan 1, 1988·Neurobiology of Aging·A D Mooradian
Jan 1, 1967·Histochemie. Histochemistry. Histochimie·F JoóB Csillik
Jan 1, 1966·Experimental Brain Research·F Joó, B Csillik
Jan 1, 1982·Annals of the New York Academy of Sciences·H M Wisniewski, P B Kozlowski
Sep 1, 1981·Journal of Neurochemistry·Z RakonczayJ P Zanetta
Jan 1, 1995·Progress in Histochemistry and Cytochemistry·P G Layer, E Willbold
Sep 1, 1995·Neurochemical Research·F MoriE Giacobini
Apr 1, 1996·Neuron·N C InestrosaJ Garrido
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M H BassantY Lamour
Jan 1, 1996·Alzheimer Disease and Associated Disorders·R E BeckerS Vicari
Aug 1, 1997·Progress in Neurobiology·P KásaK Gulya
Feb 4, 1998·Brain Research·S DachirA Levy
May 22, 1998·Neurology·J C MorrisB Gulanski
Aug 24, 1999·Neurochemistry International·R D Hurst, J B Clark
Apr 26, 2000·Brain Research Bulletin·G Allt, J G Lawrenson
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Sep 2, 1949·Science·M E Greig, W C Holland
Citations
Aug 19, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Betul Karademir CatalgolBuket Alpertunga
Oct 28, 2004·Mutation Research·Suna CukurcamUrsula Eichenlaub-Ritter
Dec 12, 2002·Journal of Toxicology. Clinical Toxicology·J Kassa
Sep 29, 2011·Toxicology Mechanisms and Methods·Miroslav PohankaJiri Pikula
Nov 22, 2018·Frontiers in Cellular Neuroscience·Orly RavidItzik Cooper