PMID: 2818202Jan 1, 1989

Effects of chronic n-hexane exposure on nervous system-specific and muscle-specific proteins

Archives of Toxicology
J HuangY Takeuchi


Two kinds of nervous system-specific and muscle-specific proteins, enolase and S-100 protein, were quantitatively determined in peripheral nerves and skeletal muscles of rats chronically exposed to a neurotoxic solvent - n-hexane. Three groups of animals were exposed to n-hexane vapor at three different solvent concentrations (500 ppm, 1200 ppm, 3000 ppm) for 12 h/day, 7 days/week for 16 weeks. The body weight gain and motor nerve conduction velocity (MCV) in exposure groups show progressively concentration-dependent decreases compared to control values. Histopathological examination also demonstrates the degeneration of peripheral nerves in 3000 ppm- and 1200 ppm-exposed rats. The significant decrease in the amount of S-100 protein in peripheral nerves was observed not only in the high level exposure groups (3000 ppm and 1200 ppm), but also in the lowest level group (500 ppm), although the MCV and morphological examination remained unchanged at this level. In addition, the muscle-specific S-100 protein in 3000 ppm exposed rats' soleus also displayed a significant reduction. In contrast to this, however, enolase isozymes were not significantly changed by either dosage level in both nervous tissue and skeletal muscle. The experi...Continue Reading


Jan 20, 1978·Science·D SchmechelF K Goodwin
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Apr 19, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hailan WangYasuhiro Takeuchi
Sep 1, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Todd StedefordChing-Hung Hsu

Related Concepts

n-hexane, 3-(13)C-labeled cpd
Electrophysiology (Science)
Muscle Proteins
Nerve Tissue Proteins
Nervous System Disorder
Nerve Conduction Function

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