PMID: 2818202Jan 1, 1989

Effects of chronic n-hexane exposure on nervous system-specific and muscle-specific proteins

Archives of Toxicology
J HuangY Takeuchi

Abstract

Two kinds of nervous system-specific and muscle-specific proteins, enolase and S-100 protein, were quantitatively determined in peripheral nerves and skeletal muscles of rats chronically exposed to a neurotoxic solvent - n-hexane. Three groups of animals were exposed to n-hexane vapor at three different solvent concentrations (500 ppm, 1200 ppm, 3000 ppm) for 12 h/day, 7 days/week for 16 weeks. The body weight gain and motor nerve conduction velocity (MCV) in exposure groups show progressively concentration-dependent decreases compared to control values. Histopathological examination also demonstrates the degeneration of peripheral nerves in 3000 ppm- and 1200 ppm-exposed rats. The significant decrease in the amount of S-100 protein in peripheral nerves was observed not only in the high level exposure groups (3000 ppm and 1200 ppm), but also in the lowest level group (500 ppm), although the MCV and morphological examination remained unchanged at this level. In addition, the muscle-specific S-100 protein in 3000 ppm exposed rats' soleus also displayed a significant reduction. In contrast to this, however, enolase isozymes were not significantly changed by either dosage level in both nervous tissue and skeletal muscle. The experi...Continue Reading

References

Jan 20, 1978·Science·D SchmechelF K Goodwin
Jan 1, 1978·Journal of Neurochemistry·E Bock
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S MonacoP Gambetti
Sep 1, 1968·Journal of Neurochemistry·V J Perez, B W Moore
Jun 30, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·K KatoY Takahashi
Apr 1, 1984·Scandinavian Journal of Work, Environment & Health·T KyrklundP Kjellstrand
Mar 1, 1981·Journal of Neurochemistry·K KatoY Umeda
Dec 1, 1981·Journal of Neurology, Neurosurgery, and Psychiatry·J A RoydsC B Taylor
Jan 1, 1980·Journal of the Neurological Sciences·F MichettiG Rigon
Jan 1, 1980·Archives of Toxicology·K G HaglidC Briving
Jul 1, 1980·Circulation Research·S WallensteinJ L Fleiss
Aug 1, 1980·British Journal of Industrial Medicine·Y TakeuchiY Sugiura

Citations

Apr 19, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hailan WangYasuhiro Takeuchi
Sep 1, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Todd StedefordChing-Hung Hsu

Related Concepts

n-hexane, 3-(13)C-labeled cpd
Electrophysiology (Science)
Isohexanes
Muscle Proteins
Muscle
Nerve Tissue Proteins
Nervous System Disorder
Nerve Conduction Function
Perineurium
Alpha-Enolase

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