Effects of chronic naltrexone treatment in rats on place preference and locomotor activation after acute administration of cocaethylene or ethanol plus cocaine

Alcohol
Helen J K SableRhea E Steinpreis

Abstract

When cocaine and ethanol are taken together a cocaine metabolite called cocaethylene is produced. Investigators have determined that cocaine, ethanol, and cocaethylene all produce a conditioned place preference when administered intraperitoneally. On the basis of the moderate success of naltrexone at attenuating the rewarding effects of ethanol and cocaine administered independently, we examined the ability of chronic naltrexone treatment (administered by means of subcutaneous implant across 6 days) to reduce the preference and motor-stimulating effects resulting from intraperitoneal administration of cocaethylene (Experiment 1) and the co-administration of ethanol with cocaine (Experiment 2) in outbred rats. Results demonstrated naltrexone modestly reduced conditioned place preference for cocaethylene but had no effect on the locomotor stimulation resulting from cocaethylene administration. Naltrexone failed to decrease the preference for the chamber paired with co-administration of ethanol and cocaine and did not change the degree of locomotor activation produced by these drugs. These results support the suggestion that naltrexone as a pharmacotherapy to treat co-abuse of ethanol and cocaine in human beings may have limited b...Continue Reading

References

Nov 1, 1979·Behavioral and Neural Biology·C L Cunningham
Nov 1, 1992·Archives of General Psychiatry·J R VolpicelliC P O'Brien
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R SpanagelT S Shippenberg
Mar 1, 1992·Brain Research. Molecular Brain Research·Y L HurdC R Gerfen
Aug 25, 1992·European Journal of Pharmacology·K MenkensF Porreca
Jul 1, 1992·Journal of Psychoactive Drugs·M J Landry
Jan 1, 1992·Life Sciences·E J BilskyL D Reid
Jan 1, 1991·Psychopharmacology·W A Corrigall, K M Coen
Nov 1, 1990·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·N F Ramsey, J M van Ree
Jan 1, 1990·Psychopharmacology·J L NeisewanderM T Bardo
Feb 1, 1990·Pharmacology, Biochemistry, and Behavior·M A Bozarth
Feb 1, 1990·Drug and Alcohol Dependence·B F Grant, T C Harford
Mar 1, 1987·Pharmacology, Biochemistry, and Behavior·P J ElliottC B Nemeroff
May 1, 1986·Pharmacology, Biochemistry, and Behavior·J MasurA P Zwicker
Jan 1, 1981·Psychopharmacology·G D Frye, G R Breese
Feb 1, 1981·Pharmacology, Biochemistry, and Behavior·C L Cunningham
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·G V MiltonC K Erickson
Jun 1, 1995·Pharmacology, Biochemistry, and Behavior·M D Schechter
Jan 1, 1993·Pharmacology, Biochemistry, and Behavior·P Päivärinta, E R Korpi
Jul 1, 1993·Pharmacology, Biochemistry, and Behavior·H C Jackson, D J Nutt
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·M D Schechter, D J Calcagnetti
Feb 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·R D Myers, M F Lankford
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·R B StewartT K Li
Nov 1, 1996·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·P BienkowskiW Kostowski
Jun 1, 1997·Alcoholism, Clinical and Experimental Research·K G Hill, S W Kiefer
Jun 1, 1997·Alcoholism, Clinical and Experimental Research·D Davidson, Z Amit
Aug 1, 1997·Pharmacology, Biochemistry, and Behavior·D V GauvinF A Holloway
Feb 26, 1998·Pharmacology, Biochemistry, and Behavior·N M Bormann, C L Cunningham
May 15, 1998·Alcoholism, Clinical and Experimental Research·J A ChesterC L Cunningham
Oct 13, 1998·Psychopharmacology·D HershH R Kranzler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

Pharmacology, Biochemistry, and Behavior
M D Schechter
Drug Metabolism and Disposition : the Biological Fate of Chemicals
M A Hedaya, W J Pan
Drug Metabolism and Disposition : the Biological Fate of Chemicals
S C Laizure, Robert B Parker
© 2021 Meta ULC. All rights reserved