PMID: 9446711Mar 21, 1998Paper

Effects of chronic nicotine ingestion on pressor response to Nomega-Nitro-L-arginine methyl ester and ex vivo concentration and relaxation response of aorta to L-arginine

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
S HuiB Qiu

Abstract

Effects of nitric oxide synthase inhibition on blood vessels were studied in nicotine-treated rats. Male Sprague-Dawley rats drank a nicotine solution with a concentration of 25 or 50 microg/ml for 15 days. The blood pressure and heart rate of chloralose-anaesthetized rats and isolated aortic strip contractions were measured. NomegaNitro-L-arginine methyl ester (L-NAME)-induced hypertension was significantly reduced after chronic nicotine treatment. The Emax of contractions of isolated aortic strips to noradrenaline were dose-dependently enhanced by nicotine and the potentiation was abolished by L-arginine. The relaxation of aortic strips to acetylcholine was significantly decreased in nicotine-treated rats, whereas L-arginine, but not D-arginine, reversed this action. Neither nicotine nor L-NAME affected the heart rate. The results show that chronic nicotine treatment reduced the pressor response of L-NAME.

Citations

Apr 12, 2005·Journal of Cardiovascular Pharmacology·Salma Toma HannaRui Wang
Jul 19, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Adam E MullickJohn C Rutledge
Nov 3, 2009·European Journal of Pharmacology·Anna L B Jacob-FerreiraJose E Tanus-Santos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.