Effects of chronic nitric oxide inhibition on the renal excretory response to leptin

Obesity Research
Daniel VillarrealRonald H Freeman

Abstract

Previous investigations have demonstrated that leptin promotes natriuresis with a renal tubular effect. However, the mechanisms involved in this response are unclear. The present study was designed to examine the hypothesis that the natriuretic response to leptin in normotensive Sprague-Dawley rats is regulated by nitric oxide (NO). The hemodynamic and renal excretory effects of intravenous bolus administration of pharmacological doses of synthetic murine leptin were examined in groups of control Sprague-Dawley rats (n = 8), Sprague-Dawley rats treated for 4 days with the NO synthase inhibitor Nomega-nitro-L-arginine methyl ester (L-NAME) (n = 8), and Sprague-Dawley rats treated for 4 days with L-NAME followed by acute treatment with sodium nitroprusside (n = 8). In the control group (n = 8), an intravenous bolus of leptin, 400 microg/kg body weight, increased urinary sodium excretion 4- to 6-fold. In the Sprague-Dawley rats chronically administered l-NAME (n = 8), an intravenous bolus of 400 microg/kg of leptin did not increase sodium excretion. Acute sodium nitroprusside infusion to Sprague-Dawley rats chronically treated with L-NAME (n = 8) was associated with partial restoration of the sodium excretory response to leptin ad...Continue Reading

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Citations

Feb 27, 2007·Vascular Health and Risk Management·Paco E BravoEfrain Reisin
Jan 22, 2011·International Journal of Hypertension·Shilpa KshatriyaDaniel Villarreal
Oct 13, 2011·European Heart Journal·Tiberio M FrisoliFranz H Messerli
May 14, 2008·Current Hypertension Reports·Sanjeev B PatelDaniel Villarreal
Feb 22, 2013·The American Journal of the Medical Sciences·Orson GoDaniel Villarreal
Jul 17, 2007·The American Journal of the Medical Sciences·Boban MathewDaniel Villarreal
Apr 12, 2008·Chest·Justo Sierra-JohnsonBruce D Johnson
Jan 19, 2007·Regulatory Peptides·Jerzy BełtowskiEwelina Borkowska
Apr 14, 2006·Journal of Hypertension·Jerzy Bełtowski
Oct 24, 2009·Current Opinion in Nephrology and Hypertension·Shilpa KshatriyaDaniel Villarreal
Jan 31, 2006·Molecular and Cellular Biochemistry·Daniel VillarrealHuma Samar
Sep 11, 2019·Nutrients·Sara BecerrilGema Frühbeck

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