PMID: 8583351Oct 1, 1995Paper

Effects of chronic nitric oxide synthase inhibition on TNB-induced colitis in rats

The Journal of Pharmacy and Pharmacology
C J Pfeiffer, B S Qiu

Abstract

Nitric oxide (NO) synthesis is increased in ulcerative colitis, but the role of NO in colitis is poorly understood. The present study employed Nw-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase inhibitor, in rats to evaluate the effect of NO on 2,4,6-trinitrobenzenesulphonic acid (TNB)-induced colitis. L-NAME solutions were placed in subcutaneous, osmotic mini-pumps which continuously released L-NAME at 0.042, 0.208, 0.417, or 1.667 mg kg-1 h-1. L-NAME dose-dependently enhanced lesions in TNB-induced colitis. The two higher doses of L-NAME significantly increased colonic mucosal damage, although there was slight, nonsignificant reduced lesion formation with the lowest dose of L-NAME. 0.042 mg kg-1 h-1. A single dose of L-NAME at 100 mg kg-1 subcutaneously injected daily in TNB-treated rats also increased lesions, and these ulcerogenic actions of L-NAME were reversed by L-arginine but not by D-arginine (both at 500 mg kg-1, s.c.). Only the highest dose of L-NAME (mini-pump) significantly depressed myeloperoxidase (MPO) activity. Faecal occult bleeding showed a close relationship with severity of colitis. These findings suggest that there may exist a balance between NO protective and aggressive effects. In TNB-ind...Continue Reading

References

Jan 1, 1976·Digestion·B MacPherson, C J Pfeiffer
Dec 1, 1992·Gastroenterology·M E Stark, J H Szurszewski
Dec 1, 1990·British Journal of Pharmacology·I R HutchesonN K Boughton-Smith
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·L J Ignarro
May 18, 1971·Biochimica Et Biophysica Acta·P PatriarcaD Romeo
Aug 7, 1993·Lancet·N K Boughton-SmithS Moncada
Feb 20, 1993·Lancet·S J MiddletonJ O Hunter
Apr 3, 1993·Lancet·M Guslandi
Dec 1, 1993·Gastroenterology·D RachmilewitzD K Podolsky
Mar 1, 1962·Archives of Biochemistry and Biophysics·J SCHULTZ, K KAMINKER

❮ Previous
Next ❯

Citations

Jan 6, 1999·Archives of Pharmacal Research·M W SonB K Kim
Dec 13, 2006·Digestive Diseases and Sciences·Sebastian VidelaJuan-Ramon Malagelada
Jan 1, 1997·Life Sciences·R B MuijsersF P Nijkamp
Jul 21, 1998·International Journal of Immunopharmacology·A SoutheyT Sugita
Jul 7, 2001·Free Radical Biology & Medicine·R HokariS Miura
Oct 12, 2001·Journal of Physiology, Paris·C J PfeifferS K Lam
Apr 5, 2007·Nature Protocols·Stefan WirtzMarkus F Neurath
Apr 2, 1999·Alimentary Pharmacology & Therapeutics·A Perner, J Rask-Madsen
Nov 26, 1999·Journal of Gastroenterology and Hepatology·B W ChenX G Liu
Jan 27, 1998·Journal of Pediatric Gastroenterology and Nutrition·J J LevineH Trachtman
Apr 20, 2002·Journal of Pediatric Gastroenterology and Nutrition·Tryggve LjungPer M Hellström
Feb 15, 2000·Gut·D M McCafferty
Feb 9, 2016·International Journal of Experimental Pathology·Ioannis TriantafyllidisDimitrios Botsios
Mar 28, 1998·Scandinavian Journal of Gastroenterology·M HerulfJ O Lundberg
Mar 5, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Heba Abdel-AzizMohamed T Khayyal
Jun 2, 2017·Nature Protocols·Stefan WirtzMarkus F Neurath
Mar 17, 2001·Scandinavian Journal of Gastroenterology·M HerulfJ O Lundberg
Jun 27, 2001·Scandinavian Journal of Gastroenterology·R HolmaR Korpela
Nov 21, 1998·European Journal of Clinical Investigation·M Guslandi
Mar 27, 2001·European Journal of Clinical Investigation·N DikopoulosH Weidenbach
Jun 26, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bruce A VallanceStephen M Collins
Mar 3, 2017·Current Protocols in Mouse Biology·Raffaella Maria GadaletaAntonio Moschetta
Mar 2, 2019·Immunopharmacology and Immunotoxicology·Amir RashidianAhmad Reza Dehpour
Aug 16, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Steven CoonUma Sundaram
Feb 10, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Steven CoonUma Sundaram
Apr 10, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Sandra CappelloMaria Carmela Cerra
May 11, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Azucena SalasJulián Panés
Nov 1, 2002·Scandinavian Journal of Gastroenterology. Supplement·G DijkstraP L M Jansen
Jul 12, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·W P WangC H Cho
Jul 18, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·D M McCaffertyP Kubes
Nov 1, 1998·Journal of Gastroenterology and Hepatology·Ferenc Lászloa, Brendan Jr Whittle

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.