Effects of chronic oral administration of a high dose of nicorandil on in vitro contractility of rat arterial smooth muscle

European Journal of Pharmacology
K TrongvanichnamH Karaki

Abstract

Nicorandil, which is structurally a nitrate and also a nicotinamide, has a vasodilator action by stimulating cyclase and ATP-sensitive K+ channel. The aim of present study was to examine the effects of chronic oral administration of a high dose of nicorandil on in vitro vascular reactivity. Nicorandil (30 mg/kg), at a dose 6-10-times higher than to decrease blood pressure in rat, was orally administered 2-times daily for a 2-4 weeks to the rats. At the end of the administration period, thoracic aorta was isolated for in vitro study. Treatment with nicorandil for 4 weeks markedly reduced the relaxant effect of nicorandil itself and other vasodilators including sodium nitroprusside, nitric oxide, endothelium-derived relaxing factor released by carbachol, 8-Br-cyclic guanosine 3',5'-monophosphate (cGMP), a K+ channel opener, levcromakalim, and forskolin. Increase in cGMP content induced by nicorandil and sodium nitroprusside was less in the aorta from nicorandil-treated rat than in the vehicle-control rat. Chronic administration of nicorandil altered neither the contractile responses to norepinephrine nor the vasodilator effect of verapamil. On the other hand, a 4-week treatment with a dose of nicorandil (2 mg/kg) sufficient to de...Continue Reading

References

Jan 31, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·K D SchultzG Schultz
Jan 1, 1992·Journal of Cardiovascular Pharmacology·W R KukovetzG Pöch
Jan 1, 1990·European Journal of Clinical Pharmacology·W R Kukovetz, S Holzmann
Mar 1, 1990·The American Journal of Physiology·T M LincolnA E Taylor
Jun 20, 1989·The American Journal of Cardiology·N Taira
Jan 1, 1989·Pharmacology & Therapeutics·T M Lincoln
Jan 1, 1989·Journal of Molecular and Cellular Cardiology·C Romanin, W R Kukovetz
Apr 1, 1989·Drugs·J T Flaherty
Jan 1, 1985·Annual Review of Pharmacology and Toxicology·L J Ignarro, P J Kadowitz
Jan 1, 1987·Drugs·K L Axelsson, J Ahlner
Nov 1, 1988·European Journal of Pharmacology·H KarakiK Murakami
Dec 1, 1986·Giornale italiano di cardiologia·S Scardi
Dec 1, 1986·Circulation·J Abrams
Sep 1, 1984·Acta Pharmacologica Et Toxicologica·K L Axelsson, J O Karlsson
May 1, 1983·Journal of Cardiovascular Pharmacology·S Holzmann
May 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·M Endoh, N Taira

❮ Previous
Next ❯

Citations

May 29, 2009·Clinical and Experimental Pharmacology & Physiology·Stéphanie RaveaudGilles Faury
Apr 29, 1998·Journal of Cardiovascular Pharmacology·K SakaiM Tanikawa
May 16, 2002·Clinical and Experimental Pharmacology & Physiology·Stéphanie Garnier-RaveaudJean Verdetti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.