Effects of chronic restraint stress and estradiol replacement on glutamate release and uptake in the spinal cord from ovariectomized female rats.

Neurochemical Research
Leonardo Machado CremaCarla Dalmaz

Abstract

Glutamate is an excitatory neurotransmitter involved in neuronal plasticity and neurotoxicity. Chronic stress produces several physiological changes on the spinal cord, many of them presenting sex-specific differences, which probably involve glutamatergic system alterations. The aim of the present study was to verify possible effects of exposure to chronic restraint stress and 17beta-estradiol replacement on [3H]-glutamate release and uptake in spinal cord synaptosomes of ovariectomized (OVX) rats. Female rats were subjected to OVX, and half of the animals received estradiol replacement. Animals were subdivided in controls and chronically stressed. Restraint stress or estradiol had no effect on [3H]-glutamate release. The chronic restraint stress promoted a decrease and 17beta-estradiol induced an increase on [3H]-glutamate uptake, but the uptake observed in the restraint stress +17beta-estradiol group was similar to control. Furthermore, 17beta-estradiol treatment caused a significant increase in the immunocontent of the three glutamate transporters present in spinal cord. Restraint stress had no effect on the expression of these transporters, but prevented the 17beta-estradiol effect. We suggest that changes in the glutamater...Continue Reading

References

Jan 1, 1982·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·J W Phillis, P H Wu
Feb 1, 1995·The Journal of Endocrinology·M P CareyE R de Kloet
Sep 1, 1994·Neuron·J D RothsteinR W Kuncl
Nov 1, 1995·Behavioural Brain Research·M Fillenz
Jun 1, 1997·The European Journal of Neuroscience·D TrottiA Volterra
Mar 29, 2000·The Journal of Nutrition·D Attwell
Feb 22, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J L MadrigalJ C Leza
Feb 24, 2001·Neuroreport·M B LealE Elisabetsky
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·S J Lee, B S McEwen
May 23, 2001·Progress in Neurobiology·N C Danbolt
Jan 30, 2002·Brain Research·Louis P Vera-PortocarreroKarin N Westlund
Mar 20, 2002·Neurochemistry International·Rejane G TavaresDiogo O Souza
Dec 12, 2002·Stress : the International Journal on the Biology of Stress·Cheryl M McCormickNicholas W Miller
Aug 27, 2003·Neurochemical Research·Angela Sampaio TabajaraCarla Dalmaz
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Lawrence P ReaganBruce S McEwen
Aug 25, 2004·European Journal of Pain : EJP·Rebecca M CraftAnna Maria Aloisi
Sep 30, 2004·Neurochemical Research·Fernanda Urruth FontellaCarla Dalmaz
Nov 10, 2004·Neurochemical Research·Martha Elisa PredigerCarla Dalmaz
Mar 10, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye
Mar 31, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Alicia A Walf, Cheryl A Frye

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