Effects of chronic stimulation of salivary gland beta-adrenoceptors on saliva composition and caries development in the rat

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
M RybergS Sundström

Abstract

The effects of long-term beta-adrenoceptor stimulation or inhibition on parotid and submandibular glands, saliva secretion, and caries development were studied. Groups of rats were treated daily with: 0.5 or 5 mg/kg body weight of isoproterenol (IPR), 0.5 or 5 mg/kg bw propranolol (PRO), or saline. After 42 days, saliva was collected and analyzed for secretion rate, total protein, amylase, sialic acid and electrolytes. Total protein and amylase in saliva decreased and potassium increased in the high IPR group. Phosphate increased in both IPR groups and decreased in the high PRO group. The average weight of parotid glands increased 3.7 times in the high IPR group and 1.8 times in the low IPR group. Amylase and total protein in parotid gland extracts decreased in both IPR groups. The submandibular gland weight increased 1.5 times in the high IPR group. Total protein decreased in the high IPR group. There was no difference in caries development.

References

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Citations

May 29, 1998·Archives of Oral Biology·M Lenander-LumikariP Vilja
Feb 13, 2002·Australian Dental Journal·W G Young
Jun 1, 2007·American Journal of Physiology. Cell Physiology·S G VenkateshDouglas S Darling
Sep 29, 2001·Development, Growth & Differentiation·D NanbaY Hieda

Related Concepts

Amylases
Metazoa
Calcium
Carious Dentin
Novodrin
Parotid Gland
Potassium
Rexigen
August Rats
Beta-adrenergic receptor

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