Effects of Chronic Stress on Alcohol Reward- and Anxiety-Related Behavior in High- and Low-Alcohol Preferring Mice

Alcoholism, Clinical and Experimental Research
Kristen R Breit, Julia A Chester

Abstract

Stress exposure (SE) during adolescence is associated with an increased risk for the development of alcohol use disorders (AUDs). Past research has shown that SE during adolescence increases voluntary alcohol consumption in mice during adulthood; however, little is known about the positive or negative motivational aspects of this relationship. High-alcohol preferring (HAP2) and low-alcohol preferring (LAP2) male mice were exposed to stress during adolescence, stress during adulthood, or no stress. After a 30-day interim, subjects were exposed to alcohol-induced place and footshock-induced fear conditioning procedures to measure stress-induced behavioral alterations during adulthood. SE during adolescence did not increase the magnitude of alcohol-induced conditioned place preference (CPP), as hypothesized, but increased the magnitude of conditioned fear, as measured by fear-potentiated startle (FPS), in HAP2 subjects only. Regardless of stress treatment group, LAP2 subjects showed greater alcohol-induced CPP expression than HAP2 mice. HAP2 mice also showed greater FPS than LAP2 mice, as previously shown. These results in mice, taken together with past research, suggest that mice exposed to stress during adolescence do not increa...Continue Reading

References

Nov 1, 1991·Journal of Abnormal Psychology·L ChassinM Barrera
Mar 1, 1986·The International Journal of the Addictions·E W Labouvie
Dec 24, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·D B ClarkA M Hegedus
May 23, 1998·European Journal of Pharmacology·S MatsuzawaM Misawa
Jun 18, 1999·Behavior Genetics·N J GrahameL Lumeng
Aug 31, 2001·Pharmacology, Biochemistry, and Behavior·N J GrahameL Lumeng
Feb 28, 2002·Behavioural Brain Research·Giovanni LaviolaMaria Livia Terranova
Jul 28, 2005·Alcoholism, Clinical and Experimental Research·Sören SiegmundRainer Spanagel
Oct 1, 2005·Lab Animal·William T GoldeLuis L Rodriguez
Nov 22, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Julia A ChesterAdam Finegan
Nov 29, 2005·European Archives of Psychiatry and Clinical Neuroscience·Robert F AndaWayne H Giles
Apr 25, 2007·Alcoholism, Clinical and Experimental Research·Gustavo D Barrenha, Julia A Chester
May 10, 2007·Nature Protocols·Christopher L CunninghamPeter A Groblewski
Sep 14, 2007·Alcoholism, Clinical and Experimental Research·Julia A Chester, Gustavo D Barrenha
Oct 24, 2007·Alcoholism, Clinical and Experimental Research·Mei SongLin Lu
Dec 9, 2008·American Journal of Public Health·Daniel J PilowskyDeborah S Hasin
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Feb 9, 2010·Pharmacology, Biochemistry, and Behavior·Julia A Chester, Laran E Coon
Aug 19, 2011·Psychopharmacology·Howard C BeckerTamara L Doremus-Fitzwater
Aug 27, 2011·Psychological Medicine·L BoschlooD S Hasin
Oct 21, 2011·American Journal of Preventive Medicine·Ellen E BoucheryRobert D Brewer

❮ Previous
Next ❯

Citations

Aug 21, 2019·Stress : the International Journal on the Biology of Stress·Kamila Souto LeichtweisVanessa Cristiane Santana Amaral
Nov 17, 2017·Alcoholism, Clinical and Experimental Research·Marcus M WeeraJulia A Chester
Nov 10, 2020·Behavioural Brain Research·Iris MüllerJulia A Chester

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alcohol Use Disorder

Alcohol use disorder involves a pattern of alcohol consumption that includes compulsive use and a loss of control over intake of alcohol. The impact on physical health, socioeconomic factors, and psychiatric health is profound. Find the latest research on alcohol use disorder here.