PMID: 602686Nov 28, 1977Paper

Effects of chronic styrene inhalation on rat brain protein metabolism

Acta Neuropathologica
H Savolainen, P Pfäffli

Abstract

Adult male rats were exposed to 7.9 mumol/1 (300 ppm) of styrene for 2--11 weeks 6 h daily excluding Saturdays and Sundays. The exposures caused a marked styrene accumulation in brain and perinephric fat, and the accumulation tended to increase upto the 4th week. The body styrene content decreased thereafter gradually towards the end of the experiment to reach half of the styrene content of the 4th week. Serum creatine kinase activity increased at the initial stage of the exposures while serum non-specific cholinesterase was below the control range at the same time. Earliest biochemical changes were detected at the 9th week of exposure, and they included increased activity of lysosomal acid proteinase. Increased enzyme activity prevailed to the end of the exposures. Simultaneous minor alterions could be detected in spinal cord axonal protein pattern whereas water-soluble protein composition in cerebellum did not change. Biochemical alterations in brain were not accompanied by significant changes in serum enzyme activities. It is concluded that marked metabolic adaptation to inhaled styrene takes place. Serum enzyme determinations may prove valuable in the adaptation period whereas they may not reflect beginning chronically neur...Continue Reading

References

May 1, 1976·Journal of Neuropathology and Experimental Neurology·K SaidaH S Weiss
Jun 1, 1975·Environmental Health Perspectives·K C Leibman
Mar 31, 1977·Acta Neuropathologica·H SavolainenH Vainio
Sep 1, 1976·Scandinavian Journal of Work, Environment & Health·A M Seppäläinen, H Härkönen
Dec 1, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·H W ChoD Goode
Nov 15, 1976·Acta Neuropathologica·H Savolainen, H Vainio
Dec 1, 1975·Journal of Neurochemistry·T L YakshH I Yamamura
Mar 1, 1976·Scandinavian Journal of Work, Environment & Health·K EngströmJ Rantanen
Dec 3, 1971·Biochimica Et Biophysica Acta·R Lim, L W Hsu
Dec 1, 1974·Analytical Biochemistry·H MorimotoE L Bennett
Mar 24, 1972·Science·G H DeVriesC S Raine
Sep 7, 1967·Biochemical and Biophysical Research Communications·A L ShapiroJ V Maizel
Sep 28, 1970·Journal of Molecular Biology·F C Huneeus, P F Davison
Jun 1, 1969·Archives of Environmental Health·B B Shugaev

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Citations

Dec 1, 1986·Journal of Applied Toxicology : JAT·A RomanelliI Franchini
Jul 1, 1981·Archives of Environmental Contamination and Toxicology·H Savolainen, P Pfäffli
Sep 1, 1984·Archives of Toxicology·A MuttiI Franchini
Mar 1, 1984·Acta Pharmacologica Et Toxicologica·E ElovaaraH Savolainen
Oct 1, 1990·Journal of Clinical and Experimental Neuropsychology·D M WhiteB D Townes
Apr 1, 1985·Archives of Toxicology·R HusainP K Seth
Dec 23, 1998·Critical Reviews in Toxicology·A Löf, G Johanson
Jun 15, 1979·Toxicology and Applied Pharmacology·H VainioE Taskinen

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