PMID: 6413634Sep 1, 1983Paper

Effects of chronic treatment with oestrogen, an oestrogen antagonist and a potent luteinizing hormone releasing hormone agonist analogue on pituitary responsiveness to luteinizing hormone releasing hormone in the rat

The Journal of Endocrinology
J M Hall, S A Whitehead

Abstract

The rise in gonadotrophin release which occurs after ovariectomy is caused by steroid withdrawal resulting in an enhanced pituitary responsiveness to LH releasing hormone (LHRH) associated with increased LHRH release and pituitary LHRH binding. The effects of oestrogen replacement after ovariectomy and chronic treatment of intact rats with an oestrogen antagonist, tamoxifen, on LH release and in-vitro pituitary responses to LHRH have been investigated. Capsules containing crystalline oestradiol, implanted at the time of ovariectomy, completely inhibited the rise in LH release although pituitary responsiveness was greater after 10 days in the oestrogen-treated rats than in untreated ovariectomized controls. On day 4 after ovariectomy pituitary responses to LHRH were comparable in both treated and untreated groups although in both groups the responses were greater than those measured in intact dioestrous rats. Treatment with tamoxifen over a 4-day period also augmented pituitary responsiveness but only at the lowest dose (0.5 mg/kg); no effect on serum LH concentrations was observed. Higher doses of the antagonist (1 and 2 mg/kg) did not affect pituitary responses, although the highest dose did cause a significant rise in serum L...Continue Reading

Citations

Jan 1, 1988·Pharmacology & Therapeutics·S P Robinson, V C Jordan
Nov 30, 1990·The Journal of Steroid Biochemistry and Molecular Biology·W R Miller
Aug 25, 1984·Lancet·J Trachtenberg, A Pont
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·B H WooP P DeLuca
Jun 15, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Claudio A de OliveiraMichelle Leblanc
Jan 15, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Qizhi HuJai Prakash

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