Effects of chronic triclosan exposure upon the antimicrobial susceptibility of 40 ex-situ environmental and human isolates

Journal of Applied Microbiology
Ruth G LedderAndrew J McBain

Abstract

Triclosan (TCS) exposure of Escherichia coli selects for tolerant clones, mutated in their enoyl-acyl carrier protein reductase (FabI). It has been inferred that this phenomenon is widespread amongst bacterial genera and might be associated with resistance to third party agents. Ex-situ, low passage isolates of enteric, human axilla, human oral origin and bacteria isolated from a domestic drain, together with selected type cultures were exposed to escalating concentrations of TCS over 10 passages using a gradient plate technique. One fresh faecal isolate of E. coli was included as a positive control. TCS susceptibility was determined for all strains before and after exposure, whilst enteric isolates were additionally assessed for susceptibility towards chlorhexidine, tetracycline, chloramphenicol, nalidixic acid and ciprofloxacin, and the oral isolates towards chlorhexidine, tetracycline and metronidazole. Triclosan exposure of E. coli markedly decreased TCS susceptibility. TCS susceptibility also decreased for Klebsiella oxytoca, Aranicola proteolyticus and Stenotrophomonas maltophilia. Susceptibility of the remaining 35 strains to TCS and the other test agents remained unchanged. These data suggest that selection for high lev...Continue Reading

References

Apr 1, 1988·The Journal of Hospital Infection·G A AyliffeH A Lilly
Jun 1, 1996·American Journal of Infection Control·H N Bhargava, P A Leonard
Aug 26, 1998·Nature·L M McMurryS B Levy
Apr 10, 1999·The Journal of Biological Chemistry·R J HeathC O Rock
Aug 10, 2000·Molecular Microbiology·H I Zgurskaya, H Nikaido
May 23, 2001·Archives of Biochemistry and Biophysics·J VillalaínV Micol
Aug 4, 2001·Emerging Infectious Diseases·S B Levy
Aug 17, 2001·FEMS Microbiology Letters·H P Schweizer
Sep 6, 2003·Applied and Environmental Microbiology·Andrew J McBainPeter Gilbert
Oct 25, 2003·Antimicrobial Agents and Chemotherapy·Andrew J McBainPeter Gilbert
Apr 10, 2004·The Journal of Antimicrobial Chemotherapy·A D Russell
May 1, 2004·The Journal of Antimicrobial Chemotherapy·Andrew J McBainPeter Gilbert
Jul 23, 2004·The Journal of Antimicrobial Chemotherapy·L P RandallM J Woodward
Jul 27, 2004·Antimicrobial Agents and Chemotherapy·Allison E AielloElaine Larson

❮ Previous
Next ❯

Citations

Oct 6, 2012·Critical Reviews in Food Science and Nutrition·Rosa Capita, Carlos Alonso-Calleja
Aug 19, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allison E AielloStuart B Levy
Jun 30, 2007·Foodborne Pathogens and Disease·Frank M AarestrupHenrik Hasman
Jan 9, 2008·Antimicrobial Agents and Chemotherapy·David J Stickler, Gwennan L Jones
Mar 21, 2012·Antimicrobial Agents and Chemotherapy·Joe LatimerAndrew J McBain
Jun 3, 2008·Applied and Environmental Microbiology·Louise E MooreAndrew J McBain
Jan 11, 2012·Clinical Microbiology Reviews·Joanna S Brooke
Jan 15, 2013·International Journal of Breast Cancer·Enora LaasElisabeth Chéreau
Jan 18, 2016·Research in Microbiology·Amélie DeredjianSabine Favre-Bonté
Jul 31, 2010·Immunology and Allergy Clinics of North America·Andreas Wollenberg, Christina Schnopp
Dec 21, 2010·Letters in Applied Microbiology·S SalehP J Collier
Nov 6, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P GilbertP Sreenivasan
Apr 6, 2018·Antimicrobial Resistance and Infection Control·Bothyna Ghanem, Randa Nayef Haddadin
Apr 10, 2016·Applied and Environmental Microbiology·Sarah ForbesAndrew J McBain
Aug 9, 2015·Applied and Environmental Microbiology·Nicola L CowleyAndrew J McBain
Dec 17, 2008·Dermatologic Therapy·Donatella SchenaGiampiero Girolomoni
Jul 11, 2020·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Prabin ShresthaTit-Yee Wong
Feb 6, 2017·International Urology and Nephrology·Ye TianHong Tan
May 15, 2013·Journal of Periodontal Research·M P CullinanG J Seymour
Nov 1, 2021·Journal of Industrial Microbiology & Biotechnology·Laura J FoxAndrew J McBain

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.