Effects of chronic unpredictable mild stress on ovarian reserve in female rats: Feasibility analysis of a rat model of premature ovarian failure

Molecular Medicine Reports
Xiao-Yan FuWen-Qian Wang

Abstract

Premature ovarian failure (POF) results from a number of disorders. The POF model is primarily based on chemotherapeutic injury, and hence is not suitable for assessing the effects of chronic stress on ovarian function. Therefore, improved animal models are required to analyze the effects of chronic stress on ovarian reserve. The feasibility of the chronic unpredictable mild stress (CUMS) method for establishing a model of POF was examined. The depressive behavior exhibited by rats was evaluated with the open field and sucrose preference tests. Vaginal smears were obtained for assessment of the estrous cycle. The ovarian reserve of the animals was evaluated using the estrous cycle, ovarian histology and serum levels of gonadotropin releasing hormone (GnRH), follicle‑stimulating hormone (FSH), estradiol (E2), and anti‑Müllerian hormone (AMH). Compared with the control group, body weight, time spent in the center, horizontal movement, vertical frequency, consumption of sucrose, sucrose preference, number of small follicles from the rats, and serum E2, AMH and GnRH levels were significantly decreased in the CUMS group (all P<0.05). However, the estrous cycle was prolonged significantly (P<0.05) and serum FSH levels were increased ...Continue Reading

References

Apr 1, 1994·São Paulo Medical Journal = Revista Paulista De Medicina·M A HaidarG R de Lima
Feb 26, 2003·European Journal of Pharmacology·Laetitia Prut, Catherine Belzung
Jan 3, 2006·Physiology & Behavior·Stephanie L BakerCatherine Bielajew
May 26, 2006·Orphanet Journal of Rare Diseases·Paolo Beck-Peccoz, Luca Persani
Mar 8, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jerome M GoldmanRalph L Cooper
Apr 25, 2009·The Journal of Toxicological Sciences·Midori YoshidaAkiyoshi Nishikawa
Sep 8, 2009·Maturitas·Lynne T ShusterWalter A Rocca
Aug 19, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Andrew N Shelling
Jul 5, 2012·Menopause : the Journal of the North American Menopause Society·Lisa A TsengAnne B Newman
May 9, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Rafael BarraHernán E Lara
Jul 9, 2014·Menopause : the Journal of the North American Menopause Society·Amanda A AllshouseNanette F Santoro
Feb 18, 2015·Behavioural Brain Research·Jing LuAi-Min Bao
Aug 5, 2016·The Journal of Pharmacology and Experimental Therapeutics·Henry C LiuSanjay K Nigam
Apr 25, 2017·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Josef van Helden, Ralf Weiskirchen

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