Effects of Chrysophyllum albidum fruit pulp on haemodynamic parameters, pro-inflammatory markers, antioxidant parameters and critical biomolecules associated with hypertension-in vivo.

Inflammopharmacology
Folake L OyetayoGbemisola Beulah Balogun

Abstract

The effects of Chrysophyllum albidum fruit pulp on haemodynamic parameters, pro-inflammatory markers, antioxidant parameters and critical biomolecules associated with hypertension in vivo were determined. Feeding with supplemented diet with pulp reduced heart rate, mean arterial pressure, systolic and diastolic blood pressure levels of hypertensive-treated groups. Moreover, hypertensive-treated groups fed with fruit pulp supplemented diets had significantly (p < 0.05) lower level of serum pro-inflammatory markers when compared to untreated hypertensive group. Furthermore, feeding with supplemented diet with pulp and captopril administration reduced AChE, BChE, ACE, and arginase activities of hypertensive-treated groups. The fruit pulp supplemented diet also increased antioxidant status of hypertensive-treated groups. This was supported by the histopathological examination of the kidney and heart tissues. These beneficial effects could in part be the explanations of ethnomedicinal uses of the fruit pulp in the management of hypertension. Nevertheless, the higher percentage inclusion of the pulp showed higher antihypertensive effects.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Jul 1, 1971·Biochemical Pharmacology·D W Cushman, H S Cheung
Jan 1, 1981·Methods in Enzymology·B Mannervik, C Guthenberg
Aug 8, 1997·Clinica Chimica Acta; International Journal of Clinical Chemistry·L T McGrathJ H Brown
Feb 4, 1999·Hypertension·R C MorrisO Schmidlin
May 29, 1999·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S J TalerL Schwartz
Aug 9, 2002·Renal Failure·Padi S V Satyanarayana, Kanwaljit Chopra
Sep 28, 2002·Journal of Cardiovascular Pharmacology·Lorenzo A CalòAndrea Semplicini
May 1, 1959·Archives of Biochemistry and Biophysics·G L ELLMAN
Jul 1, 1961·Biochemical Pharmacology·G L ELLMANR M FEATHER-STONE
Apr 16, 2004·Journal of Cardiovascular Pharmacology·Mahmoud M El-MasFouad M Sharabi
Jan 15, 2005·Journal of Applied Physiology·D L KelloggJ V Green
May 15, 2007·Mutation Research·Ikue HayashiTomonori Hayashi
Jun 11, 2009·British Journal of Pharmacology·Sidney M Morris
Jul 22, 2010·Pharmaceutical Biology·Sandip GodseSanjay Kasture
Jan 18, 2012·Food & Function·Daniel Martínez-MaquedaBlanca Hernández-Ledesma
Mar 19, 2014·European Journal of Pharmacology·Khushwant S BhullarH P Vasantha Rupasinghe
May 16, 2014·Magnesium Research : Official Organ of the International Society for the Development of Research on Magnesium·Reinis VilskerstsMaija Dambrova
Jul 26, 2014·Electrolyte & Blood Pressure : E & BP·Sung Kyu Ha
Oct 16, 2015·PloS One·James Tosin AkinluaNick Freemantle
May 10, 2016·Journal of Clinical & Experimental Cardiology·Andrew FeyhKomal Sodhi
Nov 12, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sverre E Kjeldsen
Nov 15, 2017·Hypertension·Valorie L ChiassonBrett M Mitchell
Jun 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Douglas JacksonAndrew Fenning

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.