Effects of cigarette smoke exposure during suckling on food intake, fat mass, hormones, and biochemical profile of young and adult female rats

Endocrine
P C LisboaEgberto Gaspar de Moura

Abstract

Children from smoking mothers have a higher risk of developing obesity and associated comorbidities later in life. Different experimental models have been used to assess the mechanisms involved with this increased risk. Using a rat model of neonatal nicotine exposure via implantation of osmotic minipumps in lactating dams, we have previously shown marked sexual dimorphisms regarding metabolic and endocrine outcomes in the adult progeny. Considering that more than four thousand substances are found in tobacco smoke besides nicotine, we then studied a rat model of neonatal tobacco smoke exposure: adult male offspring had hyperphagia, obesity, hyperglycemia, hypertriglyceridemia, secondary hyperthyroidism and lower adrenal hormones. Since litters were culled to include only males and since sexual dimorphisms had already been identified in the nicotine exposure model, here we also evaluated the effects of tobacco smoke exposure during lactation on females. Wistar rat dams and their pups were separated into two groups of 8 litters each: SMOKE (4 cigarettes per day, from postnatal day 3 to 21) and CONTROL (filtered air). Offspring of both sexes were euthanized at PN21 and PN180. Changes in male offspring corroborated previous data. A...Continue Reading

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Citations

Oct 12, 2018·International Journal of Molecular Sciences·Patricia Novaes SoaresPatricia Cristina Lisboa
Apr 26, 2018·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·T C PeixotoP C Lisboa
Dec 12, 2020·Annals of Medicine·Johanna M JaakkolaOlli T Raitakari
Apr 17, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T C PeixotoP C Lisboa
Aug 2, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Rosiane A MirandaPatrícia Cristina Lisboa
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lucas PossebonAna Paula Girol

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