Effects of cigarette smoking and exposure to cadmium and lead on phenotypic variability of hepatic CYP2A6 and renal function biomarkers in men

Toxicology
Soisungwan SatarugM R Moore

Abstract

Effects of cigarette smoking and exposure to dietary cadmium (Cd) and lead (Pb) on urinary biomarkers of renal function and phenotypic variability of cytochrome P450 2A6 (CYP2A6) were investigated in a group of 96 healthy Thai men with mean age of 36.7 year (19-57 years). In non-smokers, Cd burden increased with age (r = 0.47, P < 0.001). In current smokers, Cd burden increased with both age (r = 0.45, P = 0.01) and number of cigarettes smoked per day (r = 0.32, P = 0.05). Cd-linked renal tubular dysfunction was seen in both smokers and non-smokers, but Pb-linked glomerular dysfunction was seen in smokers only, possibly due to more recent exposure to high levels of Cd and Pb, as reflected by 30-50% higher serum Cd and Pb levels in smokers than non-smokers (P < 0.05). Exposure to dietary Cd and Pb appeared to be associated with mild tubular dysfunction whereas dietary exposure plus cigarette smoking was associated with tubular plus glomerular dysfunction. Hepatic CYP2A6 activity in non-smokers showed a positive association with Cd burden (adjusted beta = 0.38, P = 0.006), but it showed an inverse correlation with Pb (adjusted beta = -0.29, P = 0.003), suggesting opposing effects of Cd and Pb on hepatic CYP2A6 phenotype. In contr...Continue Reading

References

Oct 1, 1977·Journal of Toxicology and Environmental Health·A FischbeinA Kappas
Nov 14, 1977·European Journal of Clinical Pharmacology·P A MeredithA Goldberg
Jan 1, 1987·Annals of the New York Academy of Sciences·M R MooreA A Yeung-Laiwah
Nov 27, 1985·Biochemical and Biophysical Research Communications·G CairoA Bernelli-Zazzera
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·R TenhunenR Schmid
Aug 29, 1980·Journal of Chromatography·D G WaltersR C Cottrell
Jan 1, 1993·Food Additives and Contaminants·H Galal-Gorchev
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·K D Poss, S Tonegawa
Apr 4, 1998·The Tohoku Journal of Experimental Medicine·H Fujita
Feb 15, 2000·International Archives of Occupational and Environmental Health·M IkedaK Higashikawa
Mar 11, 2000·Drug and Chemical Toxicology·E F Madden, B A Fowler
Apr 27, 2000·Toxicology·O PelkonenM Pasanen
Feb 24, 2001·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·R E PolandK M Lin
Oct 27, 2001·British Journal of Clinical Pharmacology·H RaunioO Pelkonen
Feb 12, 2002·Environmental Health Perspectives·Curtis W NoonanPatricia W Mueller
Oct 31, 2002·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Taiyi JinGunnar F Nordberg
Nov 19, 2002·The Journal of Biological Chemistry·E Christine PietschSuzy V Torti
Dec 31, 2002·Toxicology Letters·Jason R BakerPaul E B Reilly
Jun 24, 2003·Drug Discovery Today·Edward M SellersLeona C Fernandes
Sep 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Edward F DominoKari S Fedewa
Oct 28, 2003·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Neal L BenowitzPeyton Jacob

❮ Previous
Next ❯

Citations

Nov 3, 2012·The Tohoku Journal of Experimental Medicine·Soisungwan Satarug, Michael R Moore
Apr 29, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Justine BacchettaPierre Cochat
Apr 25, 2012·Bulletin of Environmental Contamination and Toxicology·Yonghua LiHairong Li
May 18, 2007·Environmental Monitoring and Assessment·Malgorzata Galazyn-SidorczukJanina Moniuszko-Jakoniuk
Jan 28, 2016·Journal of Applied Toxicology : JAT·Tania Jacobo-EstradaOlivier Barbier
Oct 26, 2006·Kidney International·E B EkongV M Weaver
Oct 5, 2011·International Journal of Hygiene and Environmental Health·Argelia CastañoJosé A Jiménez-Guerrero
May 15, 2010·Toxicology Letters·Jitbanjong Tangpong, Soisungwan Satarug
Nov 1, 2009·Environmental Toxicology and Pharmacology·Roongnapa ApinanKesara Na-Bangchang
Nov 26, 2009·Journal of Applied Toxicology : JAT·Vilena KasubaZorana Kljaković-Gaspić
Jul 5, 2005·Toxicology Letters·Jason R BakerSoisungwan Satarug
Jun 8, 2010·Theoretical Biology & Medical Modelling·Alan F SassoPanos G Georgopoulos
May 7, 2016·The Tohoku Journal of Experimental Medicine·Upa KukongviriyapanVeerapol Kukongviriyapan
Feb 25, 2006·The Tohoku Journal of Experimental Medicine·Soisungwan SatarugMichael R Moore
Jan 6, 2006·IUBMB Life·David BernhardGeorg Wick
Jun 7, 2020·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Takashi AshinoSatoshi Numazawa
Nov 1, 2012·Human & Experimental Toxicology·I AbdelazizA A Ashour
Nov 15, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Adeeb ShehzadYoung Sup Lee
Dec 7, 2018·International Journal of Environmental Research and Public Health·Sònia TorresNoelia Ramírez
Jul 11, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Hye Hyun YooDong-Hyun Kim
Oct 29, 2020·Archives of Toxicology·Jukka HakkolaOlavi Pelkonen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.