Jul 5, 2011

Effects of cigarette smoking on hearing recovery from noise-induced temporary hearing threshold shifts in mice

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Joong Ho AhnJong Woo Chung

Abstract

Cigarette smoking may potentiate noise-induced hearing loss. Many epidemiological studies have shown that cigarette smoking is a major risk factor for noise-induced hearing loss. BALB/c mice were exposed to passive smoking for 2 h/d for 2 weeks before exposure to 110-dB sound pressure level white noise for 3 hours once. Hearing was assessed via the auditory brainstem response with tone-burst stimulation and distortion product otoacoustic emissions before and at 1, 3, 5, 7, 14, 21, and 28 days after noise exposure. Oxidative stress and hypoxia were assessed by immunostaining with 8-oxoG and hypoxia-inducible factor 1α, respectively. Control mice unexposed to both smoking and noise and mice exposed to smoking only showed no shift in hearing threshold. In contrast, mice exposed to noise only or smoking plus noise showed abrupt increases in hearing threshold. In mice exposed to noise only, hearing threshold returned to prenoise levels after 2 weeks. However, in mice exposed to smoking plus noise, the loss of hearing was significantly higher, and hearing threshold did not return to the pre-exposure levels until 4 weeks later. Positive staining with 8-oxoG and hypoxia-inducible factor 1α were observed in the inner ear of the smoking-...Continue Reading

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Citations

Mentioned in this Paper

Entire Brainstem
Mice, Inbred BALB C
Auditory Threshold
Oxidative Stress
Oxidative Stress Analysis
Acoustic Trauma
Otoacoustic Emissions, Spontaneous
Threshold of Hearing
Diseases of Inner Ear
Hypoxia-Inducible Factor 1

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