PMID: 9174902May 1, 1997Paper

Effects of cilostazol on the peripheral nerve function and structure in STZ-induced diabetic rats

Journal of Diabetes and Its Complications
K UeharaS Yagihashi

Abstract

We examined the effect of cilostazol (CZ), antiplatelet agent and potent vasoactive compound, which has an inhibitory effect on tissue phosphodiesterase, on peripheral nerve in streptozotocin-induced diabetic rats. Diabetic rats were fed for 12 weeks with a chow containing 0.01% or 0.03% CZ (w/w) and the results were compared with untreated diabetic rats. The 0.03% CZ treatment significantly improved motor nerve-conduction velocity and restored nerve Na+, K(+)-ATPase activity in diabetic rats without affecting body weight and glycated hemoglobin levels, but the effects of 0.01% CZ treatment did not reach statistical difference. Elevated sorbitol and reduced myo-inositol levels in diabetic nerve tissues were not influenced by CZ treatment. Structural analysis of the sural nerve demonstrated a partial but significant effect on decreased mean myelinated fiber area and atrophic changes of the axon in diabetic rats treated with 0.01% CZ. CZ treatment inhibited reduction of pericyte area of endoneurial microvessels in diabetic rats. Expansion of endoneurial microvessels and luminal area in relation to vascular area also tended to be inhibited by CZ treatment. Thus CZ treatment ameliorated, although not completely, functional and stru...Continue Reading

References

Jun 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·J Jakobsen
Sep 1, 1977·Journal of the Neurological Sciences·D R SmithH V Rizzoli
Nov 1, 1991·Journal of Neuropathology and Experimental Neurology·J BeggsC Cleary
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R MedoriP Gambetti
Jan 1, 1989·International Review of Neurobiology·P A LowP G McManis
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P N HoffmanD L Price
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P J DyckB Zimmerman
Aug 1, 1984·The Journal of Cell Biology·P N HoffmanD L Price
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P A LowJ K Yao

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Citations

Oct 1, 1995·Diabetes/metabolism Reviews·S Yagihashi
Sep 15, 2004·Acta Neuropathologica·Kazuhiro SugimotoSoroku Yagihashi
Dec 2, 2000·European Journal of Pharmacology·Y YamamotoY Komiya
Jan 4, 2001·Diabetes Research and Clinical Practice·J NakamuraN Hotta
Feb 28, 2001·Diabetes, Obesity & Metabolism·M J Reed, K A Scribner
Jan 24, 2011·Journal of Diabetes Investigation·Soroku YagihashiKazuhiro Sugimoto
Jan 22, 2008·Microvascular Research·Jeannelyn S EstrellaAndrew P Mizisin
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Marcelo P RosaVera L Portal

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