PMID: 3321924Jan 1, 1987Paper

Effects of cisapride on gastroparesis in patients with insulin-dependent diabetes mellitus. A double-blind controlled trial

Acta Medica Scandinavica
T HavelundK Lauritsen

Abstract

Fourteen insulin-dependent diabetics with symptoms and signs of delayed gastric emptying were treated with a new prokinetic agent, cisapride. In a placebo-controlled cross-over trial no significant differences from placebo was found regarding overall symptomatic effects and effects on gastric emptying of a mixed solid/liquid isotope marked test meal. Solid emptying was most markedly delayed in diabetics compared with healthy controls, but the emptying rate was not correlated to the severity of symptoms as observed for liquid emptying. During active treatment with cisapride the amelioration of symptoms was correlated to increased emptying rates assessed by combined measure of liquid/solid gastric emptying.

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Citations

Sep 28, 2000·The American Journal of Gastroenterology·C K RaynerM Horowitz
Jun 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chung Owyang, William L Hasler
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Aug 1, 2010·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Uazman AlamRayaz Ahmed Malik
Jun 7, 2012·Clinical Pharmacokinetics·Miroslav DostalekMartina Puzanovova

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