Effects of cisplatin chemotherapy on the osseointegration of titanium implants

Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
Haytham Al-MahalawyBadr Al-Jandan

Abstract

The effect of chemotherapy on the osseointegration of dental implants has received less interest compared with radiotherapy. Thus, the aim of the current study was to investigate the effect of cisplatin chemotherapy on the osseointegration of dental implants in a rabbit model. Sixteen New Zealand White rabbits were randomly assigned to two groups of treatment of either cisplatin at 2.5 mg/kg/week for 4 weeks (n = 8) or placebo (n = 8), in which the first dose was administered 2 days prior to the surgical procedure. Each rabbit received one titanium dental implant inserted in the right distal femoral condyle. Four rabbits from each group were sacrificed 4 and 8 weeks after implant insertion. Osseointegration of the dental implants was analysed using micro-computed tomography and histomorphometric evaluation. Analysis of micro-computed tomography data and histomorphometric data showed that the osseointegration parameters, including the ratio of bone volume to total volume (BV/TV) and bone-implant contact (BIC%) for the cisplatin group, were significantly lower compared to the control group at 4 and 8 weeks. (P ≤ 0.05). Cisplatin chemotherapy had a negative effect on the osseointegration of dental implants when inserted throughout...Continue Reading

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Citations

Nov 12, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Matthias TroeltzschSven Otto
Oct 2, 2017·Journal of Clinical Periodontology·Henrique Rinaldi MatheusJuliano Milanezi de Almeida
Apr 26, 2019·Clinical Oral Implants Research·Marcos Vinícius Mendes DantasMarisa Aparecida Cabrini Gabrielli
May 1, 2020·Clinical Implant Dentistry and Related Research·Felicitas WiedenmannMichael Mayinger
Jun 20, 2019·World Journal of Surgical Oncology·Ahmad ShehadehAhmed Salem
Mar 17, 2020·Biomedical Engineering Letters·A L Overmann, J A Forsberg
Nov 13, 2020·Acta Biomaterialia·Mohammed MahriFaleh Tamimi
Feb 23, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Badr Al-JandanHaytham Al-Mahalawy
Oct 12, 2021·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Vivian Cristina Noronha NovaesJuliano Milanezi de Almeida
Feb 2, 2022·Periodontology 2000·Henning Schliephake

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