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Effects of cisplatin on matrix metalloproteinase-2 in transformed thyroid cells

Biochemical Pharmacology

Mar 15, 2010

Loredana UrsoSanto Marsigliante

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Abstract

We investigated the effects of cisplatin (cisPt) on matrix metalloproteinase-2 (MMP-2) gelatinolitic activity in transformed PC E1Araf rat thyroid cells. Cells incubated with increasing cisPt concentrations showed dose- and time-dependent decrease of the MMP-2 protein and activity. CisP...read more

Mentioned in this Paper

NSC-119875
Cell Secretion
Apoptosis, Intrinsic Pathway
Antineoplastic Agents
Protein Translocation
Plasma Membrane
AP5Z1 gene
MMP-2 Activity
Gene Expression Regulation, Enzymologic
Cytoplasmic Matrix
Paper Details
References
  • References29
  • Citations4
123

Effects of cisplatin on matrix metalloproteinase-2 in transformed thyroid cells

Biochemical Pharmacology

Mar 15, 2010

Loredana UrsoSanto Marsigliante

PMID: 19874802

DOI: 10.1016/j.bcp.2009.10.013

Abstract

We investigated the effects of cisplatin (cisPt) on matrix metalloproteinase-2 (MMP-2) gelatinolitic activity in transformed PC E1Araf rat thyroid cells. Cells incubated with increasing cisPt concentrations showed dose- and time-dependent decrease of the MMP-2 protein and activity. CisP...read more

Mentioned in this Paper

NSC-119875
Cell Secretion
Apoptosis, Intrinsic Pathway
Antineoplastic Agents
Protein Translocation

Related Papers

Paper Details
References
  • References29
  • Citations4
123

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