Effects of citrus leaf extract on aortic vascular reactivity in hypertensive rats fed repeatedly heated vegetable oil

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Hawa Nordin SitiKamsiah Jaarin

Abstract

The prolonged intake of diet containing repeatedly heated vegetable oil can cause hypertension in the long run. In this study, the effects of citrus leaf extract (CLE) supplementation on vascular reactivity, plasma nitrite, and aortic structure in hypertensive rats were investigated by the consumption of repeatedly heated vegetable oil [corrected]. Male Sprague Dawley rats (n = 56) were divided into 7 groups corresponding to the respective diets. For 16 weeks, 1 group was given standard rat chow (control) while other groups were given diets containing 15% w/w of palm oil, fresh palm oil (FPO), palm oil heated 5 times (5HPO), and palm oil heated 10 times (10HPO), with or without the incorporation of 0.15% w/w CLE (FPO+CLE, 5HPO+CLE, or 10HPO+CLE). Plasma nitrite levels were measured before and at 16 weeks of treatment. After 16 weeks, the rats were sacrificed and aortae were harvested for measuring vascular reactivity and for microscopic study. CLE supplementation had significantly reduced the loss of plasma nitrite and attenuated the vasoconstriction response to phenylephrine in the 5HPO group but not in the 10HPO group. However, CLE had no significant effect on the vasorelaxation response to acetylcholine and sodium nitroprus...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J S StamlerJ Loscalzo
Feb 1, 1992·Hypertension·T F LüscherZ H Yang
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·S L ArcherE K Weir
Dec 28, 2005·Diabetes Research and Clinical Practice·Machha AjayMohd Rais Mustafa
Feb 21, 2006·Pharmacology & Therapeutics·Silvia M ArribasM Carmen González
Sep 7, 2006·The Journal of Clinical Investigation·Johannes-Peter StaschHarald H H W Schmidt
May 22, 2007·Nitric Oxide : Biology and Chemistry·Ajay MachhaMohd Rais Mustafa
Aug 2, 2007·Nature Reviews. Drug Discovery·Csaba SzabóRafael Radi
Aug 29, 2009·The Tohoku Journal of Experimental Medicine·Xin-Fang LeongKamsiah Jaarin
Nov 12, 2010·The American Journal of Clinical Nutrition·Christine MorandAndrzej Mazur
Feb 23, 2011·Clinical Hemorheology and Microcirculation·Belqes Abdullah Al-TahamiAida Hanum Ghulam Rasool
Feb 1, 2012·Journal of Cardiovascular Translational Research·Jessica E Wagenseil, Robert P Mecham
Sep 15, 2012·International Journal of Experimental Pathology·Chun-Yi NgKamsiah Jaarin
Jul 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Badlishah Sham Nurul-ImanHj Mohd Saad Qodriyah
Jan 10, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hawa Nordin SitiKamsiah Jaarin

❮ Previous
Next ❯

Citations

Jun 3, 2021·International Journal of Molecular Sciences·Hawa Nordin SitiYusof Kamisah
Aug 4, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kumar Ganesan, Baojun Xu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Related Papers

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Hawa Nordin SitiKamsiah Jaarin
Evidence-based Complementary and Alternative Medicine : ECAM
Badlishah Sham Nurul-ImanHj Mohd Saad Qodriyah
Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Yusof KamisahHj Mohd Saad Qodriyah
© 2022 Meta ULC. All rights reserved