PMID: 8589500Aug 1, 1995Paper

Effects of clenbuterol on rabbit vesicourethral muscle contractility

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
T MoritaT Kishimoto

Abstract

Clenbuterol (10(-10)-10(-7) M), a selective beta 2-adrenoceptor agonist, reduced spontaneous contractile force of isolated rabbit bladder dome, bladder base and proximal urethra. Clenbuterol inhibited both acetylcholine (Ach)-and electrical field stimulation (EFS)-induced contractions of rabbit bladder dome, but was more potent in inhibiting EFS-than Ach-induced contractions. Acetylcholine-but not EFS-induced contractions in the bladder dome were completely inhibited by pretreatment with 10(-6) M atropine. The atropine resistant component of the EFS-induced contractions was completely inhibited by tetrodotoxin, 10(-6) M. Clenbuterol and a non-selective beta-adrenoceptor agonist, isoproterenol, potentiated the EFS-induced contractions of isolated striated muscle preparations from the external urethral sphincter and from the extensor digitorum longus in the rabbit. Clenbuterol was more potent than isoproterenol in increasing EFS-induced contractile force in the external urethral sphincter, whereas isoproterenol was more potent than clenbuterol in increasing EFS-induced contractile force in the extensor digitorum longus. These data suggest that clenbuterol may have a role in the treatment of urinary incontinence by inhibiting the ...Continue Reading

Citations

Oct 25, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·O IshikoS Ogita
May 18, 2007·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Noriyuki Masuda, Masanori Suzuki
Jun 1, 2000·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·T MoritaS Kondo
Nov 27, 2009·Autonomic Neuroscience : Basic & Clinical·C H FryJ S Young
Dec 17, 2004·Pharmacological Reviews·Karl-Erik Andersson, Alan J Wein
Jun 5, 1998·The American Journal of Physiology·A J BakkerD G Stephenson

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