Effects of clomiphene citrate on male obesity-associated hypogonadism: a randomized, double-blind, placebo-controlled study

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Andressa Heimbecher SoaresCintia Cercato

Abstract

Obesity causes secondary hypogonadism (HG) in men. Standard testosterone (T) replacement therapy improves metabolic parameters but leads to infertility. To evaluate clomiphene citrate (CC) treatment of adult men with male obesity-associated secondary hypogonadism (MOSH). Single-center, randomized, double-blind, placebo-controlled trial. Seventy-eight men aged 36.5 ± 7.8 years with a body mass index (BMI) > 30 kg/m2, total testosterone (TT) ≤ 300 ng/dL, and symptoms in the ADAM questionnaire. Random allocation to receive 50 mg CC or placebo (PLB) for 12 weeks. (1) Clinical features: ADAM and sexual behavior questionnaires; (2) hormonal profile: serum TT, free T, estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG); (3) body composition: BMI, waist circumference, and bioelectric impedance analysis; (4) metabolic profile: blood pressure, fasting blood glucose, HbA1c, insulin, HOMA-IR, and lipid profile; (5) endothelial function: flow-mediated dilation of the brachial artery, quantitative assessment of endothelial progenitor cells and serum sICAM-1, sVCAM-1, and selectin-sE levels; (6) safety aspects: hematocrit, serum prostate-specific antigen, International Prostate...Continue Reading

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Dec 12, 2018·Endocrine Connections·Alessandra Gambineri, Carla Pelusi
Apr 16, 2019·F1000Research·Tharu TharakanSuks Minhas
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Jan 9, 2022·International Journal of Impotence Research·Maria Camila Suarez ADaniel E Nassau

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Methods Mentioned

BETA
testosterone replacement therapy
nuclear magnetic resonance
enzyme-linked immunosorbent assay
flow cytometry

Clinical Trials Mentioned

NCT02380755

Software Mentioned

ADAM
SPSS
GraphPad

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