Effects of clonidine and xylazine on body temperature in the rat

British Journal of Pharmacology
A LivingstonB Morris


Clonidine and xylazine injected intraperitoneally both produced a dose-dependent hypothermia in unanaesthetized, freely moving rats. The alpha 2-antagonist yohimbine produced an antagonism of the xylazine-induced hypothermia but a potentiation of the clonidine-induced hypothermia. The opioid antagonist naloxone had little effect on the xylazine hypothermia, but potentiated the clonidine hypothermia. It is concluded that whilst the two alpha 2-agonists produce a similar hypothermic effect in the rat, they are acting by different mechanisms.


May 1, 1979·The Journal of Pharmacy and Pharmacology·B Cox, T F Lee
Nov 1, 1978·European Journal of Pharmacology·J M BarabanG Aghajanian
Jan 1, 1978·Clinical and Experimental Hypertension : CHE·D N FranzR J Neumayr
May 1, 1970·Life Sciences·N E AndénT Svensson
Jul 1, 1974·Biochemical Pharmacology·S Z Langer
Sep 1, 1968·European Journal of Pharmacology·J W Constantine, W K McShane
Sep 1, 1967·British Journal of Pharmacology and Chemotherapy·W Feldberg, V J Lotti
Dec 1, 1982·Journal of Medicinal Chemistry·P B Timmermans, P A van Zwieten


Jan 1, 1992·Veterinary Research Communications·J M Arnemo, N E Søli
Dec 6, 1988·European Journal of Pharmacology·E MacDonaldM Scheinin
Sep 1, 1995·The British Veterinary Journal·B Y Aminkov, H D Hubenov
May 12, 2001·European Journal of Pharmacology·H H BerendsenH J Kloosterboer
Oct 12, 2000·Small Ruminant Research : the Journal of the International Goat Association·P KinjavdekarA M Pawde
Mar 1, 1996·British Journal of Pharmacology·J M O'DonnellT Kovacs
Jun 15, 2010·Research in Veterinary Science·J Santiago-MorenoA López-Sebastián
Oct 22, 2008·European Journal of Pharmacology·Jyrki LehtimäkiRaimo Virtanen
Oct 3, 2007·Acta Ophthalmologica Scandinavica·Fengju ZhangPer G Söderberg
Jul 29, 2015·Journal of Animal Science and Biotechnology·Yuri R MontanholiStephen P Miller
Feb 6, 2004·Veterinary Anaesthesia and Analgesia·Helene M ChevalierAlicia Z Karas
Sep 1, 1988·Journal of Autonomic Pharmacology·S G KamerlingC A Bagwell
Oct 15, 2011·Pharmacology·Shridhar V Andurkar, Anil Gulati
Jan 1, 1986·Journal of Ocular Pharmacology·J A Burke, D E Potter
Sep 20, 2018·PloS One·Katharina HohlbaumChrista Thöne-Reineke
Nov 26, 2009·The Psychoanalytic Quarterly·Elizabeth Spillius

Related Concepts

Dose-Response Relationship, Drug
Drug Interactions
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
August Rats
Xylazine Phosphate (1: 1)
Yohimbin Spiegel
Rats, Laboratory

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