Effects of clonidine and xylazine on body temperature in the rat

British Journal of Pharmacology
A LivingstonB Morris

Abstract

Clonidine and xylazine injected intraperitoneally both produced a dose-dependent hypothermia in unanaesthetized, freely moving rats. The alpha 2-antagonist yohimbine produced an antagonism of the xylazine-induced hypothermia but a potentiation of the clonidine-induced hypothermia. The opioid antagonist naloxone had little effect on the xylazine hypothermia, but potentiated the clonidine hypothermia. It is concluded that whilst the two alpha 2-agonists produce a similar hypothermic effect in the rat, they are acting by different mechanisms.

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Related Concepts

Metazoa
Isoglaucon
Dose-Response Relationship, Drug
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Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
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Xylazine Phosphate (1: 1)
Yohimbin Spiegel
Rats, Laboratory

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