Effects of Clonidine on the Cardiovascular, Renal, and Inflammatory Responses to Experimental Bacteremia

Shock
Paolo CalzavaccaC N May

Abstract

Supra-clinical doses of clonidine appear beneficial in experimental sepsis, but there is limited understanding of the effects of clonidine at clinically relevant doses. In conscious sheep, with implanted renal and pulmonary artery flow probes, sepsis was induced by infusion of live Escherichia coli. At 24 h, a high clinical dose of clonidine (HCDC) [1.0 μg/kg/h], a low clinical dose of clonidine (LCDC) [0.25 μg/kg/h] or vehicle, was infused for 8 h. Animals developed hyperdynamic, hypotensive sepsis with acute kidney injury. The HCDC decreased heart rate (153 ± 6 to 119 ± 7 bpm) and cardiac output (5.6 ± 0.4 to 5.0 ± 0.4 L/min), with no reduction in mean arterial pressure (MAP). In contrast, LCDC increased cardiac output with peripheral vasodilatation. Both doses induced a large transient increase in urine output, an increase in plasma osmolality and, with the high dose, an increase in plasma arginine vasopressin. Sepsis increased plasma interleukin-6 (IL-6) and IL-10 and clonidine further increased IL-10 (1.6 ± 0.1 to 3.3 ± 0.7 ng/mL), but not IL-6. Clonidine reduced rectal temperature. During recovery from sepsis, MAP returned to baseline values more rapidly in the HCDC group (P < 0.001). In hyperdynamic, hypotensive sepsis, ...Continue Reading

References

Feb 1, 1977·Japanese Journal of Pharmacology·H OzawaT Uematsu
Dec 1, 1988·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·J S KoonerC J Mathias
Aug 1, 1972·European Journal of Pharmacology·W Kobinger, A Walland
Feb 7, 1998·Journal of Veterinary Pharmacology and Therapeutics·C S CellyS S Young
Jun 27, 2001·Journal of Cardiothoracic and Vascular Anesthesia·A KumarJ E Parrillo
May 11, 2005·Cardiovascular Drugs and Therapy·Anna MitchellJens Nürnberger
Feb 7, 2009·Critical Care : the Official Journal of the Critical Care Forum·Stefan HoferMarkus A Weigand
Sep 4, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rohit RamchandraClive N May
Sep 8, 2010·Medical Hypotheses·C PichotL Quintin
Sep 6, 2011·Critical Care : the Official Journal of the Critical Care Forum·Mervyn Singer, Michael A Matthay
Aug 31, 2012·American Journal of Physiology. Renal Physiology·Chung-Hsi HsingChing-Hua Yeh
Dec 19, 2012·Journal of the American Society of Hypertension : JASH·Louise M BurrellColin I Johnston
Jan 15, 2014·The Journal of Physiology·D MartelliR M McAllen
Nov 22, 2014·Critical Care : the Official Journal of the Critical Care Forum·Paolo CalzavaccaClive N May
Apr 11, 2015·Critical Care Medicine·Yugeesh R LankadevaClive N May

❮ Previous
Next ❯

Citations

Nov 27, 2018·Shock·Hongkuan Fan, Andrew J Goodwin
Jul 10, 2019·Acta Anaesthesiologica Scandinavica·Cornelia KnaakGunnar Lachmann
Nov 27, 2020·Critical Care Medicine·Yugeesh R LankadevaClive N May
Jan 16, 2021·British Journal of Pharmacology·Yugeesh R LankadevaClive N May
Sep 18, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Estelle B GaudaVijay Ivaturi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.