Effects of clopidogrel therapy on oxidative stress, inflammation, vascular function, and progenitor cells in stable coronary artery disease

Journal of Cardiovascular Pharmacology
Ronnie RamadanArshed A Quyyumi

Abstract

Traditional cardiovascular risk factors lead to endothelial injury and activation of leukocytes and platelets that initiate and propagate atherosclerosis. We proposed that clopidogrel therapy in patients with stable coronary artery disease imparts a pleiotropic effect that extends beyond antiplatelet aggregation to other atheroprotective processes. Forty-one subjects were randomized in a double-blind, placebo-controlled, crossover study to receive either clopidogrel 75 mg daily or placebo for 6 weeks and then transitioned immediately to the other treatment for an additional 6 weeks. We assessed (1) endothelial function as flow-mediated dilation of the brachial artery, (2) arterial stiffness and central augmentation index using applanation tonometry, (3) vascular function as fingertip reactive hyperemia index, (4) inflammation by measuring plasma CD40 ligand and serum high-sensitivity c-reactive protein levels, (5) oxidative stress by measuring plasma aminothiols, and (6) circulating progenitor cells, at baseline and at the end of each 6-week treatment period. Clopidogrel therapy resulted in a significant reduction in soluble CD40 ligand (P = 0.03), a prothrombotic and proinflammatory molecule derived mainly from activated plate...Continue Reading

Associated Clinical Trials

Jan 25, 2011·Arshed A. Quyyumi, Arshed A. Quyyumi

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Jan 14, 2016·British Journal of Pharmacology·Sven Nylander, Rainer Schulz
Oct 6, 2015·Sports Medicine - Open·Chun-Jung HuangEdmund O Acevedo
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·T G MastenbroekJ M E M Cosemans
Mar 24, 2015·Frontiers in Immunology·Henry M NordingHarald F Langer
Jan 22, 2019·Current Medicinal Chemistry·Anastasios TentolourisNikolaos Tentolouris

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