PMID: 21122449Dec 3, 2010Paper

Effects of clotrimazole on the growth of oral squamous cell carcinoma

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Hui LiuGui-Yuan Li

Abstract

to investigate the effects of clotrimazole on the growth of oral squamous cell carcinoma (OSCC). OSCC-25 cells growing in log phase were treated with various doses of clotrimazole. The concentration of IC(50), cell cycle and cell cycle related protein were examined. the concentration of clotrimazole for inhibiting OSCC was IC(50) 8.51 µmol/L. Clotrimazole induced cell cycle arrest in the G(0)-G(1) cell cycle phase, with a concomitant decrease of cells in the G(2)-M and S-phase. Furthermore, clotrimazole significantly decreased the levels of cyclin D, cyclin E and CDK-4. clotrimazole inhibits the growth of OSCC.

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