Aug 1, 1977

Effects of clozapine (Leponex) on sleep patterns in the cat

Archives internationales de physiologie et de biochimie
V SusićG Masirević


This study examined the effects of clozapine on sleep-wakefulness profile in cats prepared for chronic recording of sleep. Clozapine in single dose (i.p.) of 5 mg/kg drastically reduced slow-wave sleep (SWS) and paradoxical sleep (PS), while wakefulness and drowsy pattern were increased. These changes lasted approximately 24 h and were followed by sleep recovery. PS had a priority of recovery. Some similarities between clozapine effects on sleep in cat and human were mentioned.

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Mentioned in this Paper

Slow Virus Diseases
Sleep, Slow-Wave
Sleep Stages
Sleep, REM
Felis catus
DRUG Screen Quantitative Clozapine

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