Effects of CO2 exposure on distribution of various forms of iron and copper in guinea-pig tissues

Experientia
K E Schaefer, M C Linder

Abstract

The effects on iron and copper distribution and metabolism of exposure to high levels of CO2 were studied in the guinea-pig. Mature, male animals were placed in an atmosphere of 15% CO2, 21% O2 (balance N2), and sacrificed from 1 h to 1 week thereafter. Total iron and copper concentrations of blood, liver, spleen and bone, as well as concentrations of heme and ferritin iron, were measured together with blood hematocrit, reticulocytes, plasma hemoglobin, plasma ceruloplasmin and copper concentrations. The results show clearly that rapid and sustained red cell damage or hemolysis ensued several h from the start of CO2 treatment. This resulted in loss of iron and copper from the blood, an influx of both elements into liver, spleen and bone, and a rise in plasma ceruloplasmin. Influx of iron into liver and spleen caused an accumulation of ferritin, the main site for iron storage in cells. Following the effect on red cells, there was an accumulation of heme iron, and a decreased hematocrit, best explained by a depressed activity of the reticuloendothelial and erythropoietic systems. A period of adaptation succeeded these events, in which all blood parameters and most tissue values returned to normal, despite the continuing presence ...Continue Reading

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Citations

Apr 1, 1989·Journal of Child and Adolescent Psychiatric and Mental Health Nursing·C M Raynor, M A Manderino
Feb 7, 2003·The American Journal of Clinical Hypnosis·Julie H Linden
Jan 1, 1992·Child Psychiatry and Human Development·K D Atala, B D Carter
Dec 21, 2006·Behavior Modification·Kristi D WrightSusan E Buffett-Jerrott

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