Effects of CO2 water-bath treatment on blood flow and angiogenesis in ischemic hind limb of diabetic rat

Canadian Journal of Physiology and Pharmacology
Yan-Jun XuNaranjan S Dhalla

Abstract

The effects of CO2 water-bath therapy on the hind limb of diabetic animals with or without peripheral ischemia were examined. Diabetes was induced in rats by administering streptozotocin (65 mg·kg-1), and the animals were then divided into 3 groups. After 4 weeks, peripheral ischemia was induced by ligation of the femoral artery for 2 weeks in 2 groups (diabetic ischemic) of diabetic rats, whereas the femoral artery was not occluded in the third group (diabetic). All these animals were subjected to water-bath therapy (with or without CO2 mixing; 20 min·day-1 for 5 days·week-1) for a period of 4 weeks. Both peak and mean flows, unlike minimal flow, in diabetic ischemic limbs were increased about a twofold by CO2 water-bath treatment. Morphological examination of hind limb tissue sections revealed about a twofold increase in the small artery count in diabetic ischemic animals upon CO2 water-bath treatment. These results indicate that CO2 water-bath therapy augments the blood flow and development of angiogenesis in the skeletal muscle of diabetic ischemic animals and thus may be of some benefit for the treatment of peripheral arterial disease in diabetes.

References

Aug 1, 1989·The Journal of Investigative Dermatology·T ItoM C Koss
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·P G LloydR L Terjung
Jun 5, 2003·Nature Medicine·Peter Carmeliet
Sep 24, 2004·Annals of Internal Medicine·Elizabeth SelvinSherita Hill Golden
Mar 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Malgorzata MilkiewiczHaley Silgram
Jul 27, 2005·Diabetes Care·Paul MuntnerVivian Fonseca
Oct 27, 2009·Ultrasound in Medicine & Biology·Anilkumar K ReddyCraig J Hartley
Jun 15, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Birgitte HøierYlva Hellsten
Oct 23, 2010·International Journal of Biometeorology·Efstathios D PagoureliasGeorgios K Efthimiadis
May 17, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Craig J HartleyGeorge E Taffet
May 20, 2011·Nature·Peter Carmeliet, Rakesh K Jain
Sep 20, 2011·Cell·Michael PotentePeter Carmeliet
Aug 19, 2014·Journal of Atherosclerosis and Thrombosis·Yasukatsu IzumiHiroshi Iwao
Sep 28, 2014·Clinical Hemorheology and Microcirculation·Miha FinzgarKsenija Cankar
Apr 25, 2015·Circulation Research·John P Cooke, Douglas W Losordo
May 21, 2015·International Journal of Molecular Sciences·Smriti Murali KrishnaJonathan Golledge
Nov 7, 2015·Molecular and Cellular Biochemistry·Sergey BolevichVladimir Jakovljevic
May 31, 2017·Molecular and Cellular Biochemistry·Yan-Jun XuNaranjan S Dhalla
Jun 16, 2017·Physiology·Naoki Sawada, Zolt Arany
Jul 14, 2017·Canadian Journal of Physiology and Pharmacology·Yan-Jun XuNaranjan S Dhalla

❮ Previous
Next ❯

Citations

Mar 25, 2020·Canadian Journal of Physiology and Pharmacology·Vijayan ElimbanNaranjan S Dhalla

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.