Effects of cocaine-amphetamine regulated transcript (CART) on hormone release

Regulatory Peptides
Bogusława BaranowskaAgnieszka Baranowska-Bik

Abstract

Cocaine- and amphetamine-regulated transcript (CART) is a recently described neuropeptide widely expressed in the rat brain. CART is abundant in hypothalamus nuclei controlling anterior pituitary function. In the paraventricular nucleus CART mRNA is colocalized with vasopressin and corticotrophin-releasing factor containing neurons. The data may suggest that CART plays a role in hypothalamic regulation of neuroenocrine functions. Male Wistar-Kyoto rats were investigated. Experiment I: CART was administered intracerebroventricularly (i.c.v.) in a dose of 0.5 microg dissolved in 5 microl vehicle. At 60, 120 min after the infusion of CART or vehicle animals were decapitated and trunk blood was collected until hormonal estimations. Experiment II: CART in a dose of 10 microg was injected intravenously (i.v.). At 60, 120, 240 min the rats were decapitated and the trunk blood was collected. Serum rLH, rFSH, rPRL, rTSH, rGH and plasma leptin, NPY concentrations were measured by RIA methods. CART administered centrally (i.c.v.) simulated significantly GH release after 60 min (p<0.05) and after 120 min (p<0.01). CART increased also PRL after 60 min (p<0.05). A marked increase of corticosterone level was observed at 60 and 120 min (p<0.01...Continue Reading

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Citations

Jan 1, 2012·Journal of Drug and Alcohol Research·Martin O Job, Michael J Kuhar
Jan 29, 2014·Peptides·Nishikant K SubhedarDadasaheb M Kokare
Apr 20, 2006·Behavioural Brain Research·Rebecca C SteinerMarina R Picciotto
May 16, 2006·Peptides·Aleksandra Vicentic
Jun 4, 2016·Hippocampus·Ashish P BharneDadasaheb M Kokare
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Nicolas Rohleder, Clemens Kirschbaum
Sep 20, 2008·Nature Reviews. Neuroscience·G RoggeM J Kuhar

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