Effects of Cocaine Self-Administration and Its Extinction on the Rat Brain Cannabinoid CB1 and CB2 Receptors

Neurotoxicity Research
Beata BystrowskaMałgorzata Filip

Abstract

The aim of this study was to evaluate changes in the expression of cannabinoid type 1 (CB1) and 2 (CB2) receptor proteins in several brain regions in rats undergoing cocaine self-administration and extinction training. We used a triad-yoked procedure to distinguish between the motivational and pharmacological effects of cocaine. Using immunohistochemistry, we observed a significant decrease in CB1 receptor expression in the prefrontal cortex, dorsal striatum, and the basolateral and basomedial amygdala following cocaine (0.5 mg/kg/infusion) self-administration. Increased CB1 receptor expression in the ventral tegmental area in rats with previous cocaine exposure was also found. Following cocaine abstinence after 10 days of extinction training, we detected increases in the expression of CB1 receptors in the substantia nigra in both cocaine groups and in the subregions of the amygdala for only the yoked cocaine controls, while any method of cocaine exposure resulted in a decrease in CB2 receptor expression in the prefrontal cortex (p < 0.01), nucleus accumbens (p < 0.01), and medial globus pallidus (p < 0.01). Our findings further support the idea that the eCB system and CB1 receptors are involved in cocaine-reinforced behaviors....Continue Reading

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Citations

Mar 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Beata BystrowskaMałgorzata Filip
Nov 25, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ani GasparyanJorge Manzanares
Dec 19, 2020·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Xia LiZheng-Xiong Xi
Jan 31, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lan-Yuan ZhangHao-Wei Shen
Mar 14, 2021·Journal of Neural Transmission·A A A Putri Laksmidewi, Andreas Soejitno
Jul 25, 2021·International Journal of Molecular Sciences·Citlalli NetzahualcoyotziMario Humberto Buenrostro-Jáuregui
Aug 23, 2021·Psychoneuroendocrinology·Heng-Ai ChangSherry Shu-Jung Hu
Jan 16, 2022·Molecular Neurobiology·David De Sa NogueiraKatia Befort

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Methods Mentioned

BETA
Infrared Imaging

Software Mentioned

Odyssey

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