Effects of cold ischemia time on the graft after orthotopic liver transplantation. A bile cytological study

Transplantation
L CarrascoP Parrilla

Abstract

We conducted a daily analysis of bile cellularity in 16 orthotopic liver transplant patients fitted with a T-tube, and correlated the cytological parameters (number of cells per slide, and percentage of difference cell types) with the duration of cold ischemia time (CIT). Two groups were established: one comprised patients whose CIT was less than 7 hr (CIT averaged 345 min) and the other comprised patients with a CIT of more than 7 hr (CIT averaged 505 min). The control group consisted of 15 patients who had received cholecystectomy for biliary lithiasis and were fitted with a T-tube. All 3 groups showed the highest cell density on the 1st postoperative day (control: 53.3 +/- 15.5 cells/slide; short ischemia: 70 +/0 21.4 cells/slide; long ischemia: 158.8 +/- 53.2 cells/slide), which steadily ischemia group showed a higher cell density than did the control group for the first 2 days, although this was not significant. The long ischemia group showed the highest cell density, although only significantly for the first 2 days when compared with the controls, and basically at the expense of a increase in ductal epithelial cells. Our results show that prolonged cold ischemia causes an increase in bile cell density at the expense of du...Continue Reading

References

Dec 1, 1989·Transplantation·K KubotaF P Reinholt
Feb 3, 1989·JAMA : the Journal of the American Medical Association·S TodoT E Starzl
Nov 1, 1987·Scandinavian Journal of Gastroenterology·E B HaagsmaC H Gips

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Citations

Jan 3, 2001·Transplantation Proceedings·F Sánchez-BuenoP Parrilla
May 12, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M Kukan, P S Haddad
Apr 25, 2012·Journal of Transplantation·Raffaele Cursio, Jean Gugenheim
Jan 28, 2014·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Ying LuoJia-Hong Dong
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Ziv Ben-AriEytan Mor
Feb 25, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nikhil B Amesur, Albert B Zajko
Apr 22, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Harm HoekstraPierre A Clavien
Oct 16, 2016·Transplantation Proceedings·M E Gámez CórdobaC Montiel Casado
Dec 9, 2010·Arquivos De Gastroenterologia·Stela Maria MotaMário Reis Alvares-da-Silva
Dec 23, 1998·Cytopathology : Official Journal of the British Society for Clinical Cytology·L CarrascoP Parrilla
Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M A SchnitzlerJ A Lowell
Jun 15, 2006·World Journal of Gastroenterology : WJG·A-J DemetrisIsao Nozaki

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