Effects of collagen microstructure and material properties on the deformation of the neural tissues of the lamina cribrosa

Acta Biomaterialia
A P VoorheesIan A Sigal

Abstract

It is widely considered that intraocular pressure (IOP)-induced deformation within the neural tissue pores of the lamina cribrosa (LC) contributes to neurodegeneration and glaucoma. Our goal was to study how the LC microstructure and mechanical properties determine the mechanical insult to the neural tissues within the pores of the LC. Polarized light microscopy was used to measure the collagen density and orientation in histology sections of three sheep optic nerve heads (ONH) at both mesoscale (4.4μm) and microscale (0.73μm) resolutions. Mesoscale fiber-aware FE models were first used to calculate ONH deformations at an IOP of 30mmHg. The results were then used as boundary conditions for microscale models of LC regions. Models predicted large insult to the LC neural tissues, with 95th percentile 1st principal strains ranging from 7 to 12%. Pores near the scleral boundary suffered significantly higher stretch compared to pores in more central regions (10.0±1.4% vs. 7.2±0.4%; p=0.014; mean±SD). Variations in material properties altered the minimum, median, and maximum levels of neural tissue insult but largely did not alter the patterns of pore-to-pore variation, suggesting these patterns are determined by the underlying struct...Continue Reading

References

Apr 1, 1981·Archives of Ophthalmology·H A QuigleyA E Maumenee
Feb 24, 2000·The British Journal of Ophthalmology·J AlbonD L Easty
Apr 5, 2000·Progress in Retinal and Eye Research·M R Hernandez
Nov 24, 2004·Investigative Ophthalmology & Visual Science·Ian A SigalC Ross Ethier
Oct 27, 2005·Investigative Ophthalmology & Visual Science·Ian A SigalC Ross Ethier
Dec 13, 2006·Journal of Biomechanical Engineering·E A SanderE A Nauman
Jun 4, 2008·Optometry and Vision Science : Official Publication of the American Academy of Optometry·J Crawford DownsClaude F Burgoyne
Feb 17, 2009·Experimental Eye Research·Ian A Sigal, C Ross Ethier
Apr 7, 2009·Bioinformatics·Stephan PreibischPavel Tomancak
Apr 25, 2009·Journal of Biomechanical Engineering·Michaël J A GirardJ-K Francis Suh
Aug 22, 2009·Investigative Ophthalmology & Visual Science·Michael D RobertsJ Crawford Downs
Sep 14, 2010·Journal of Biomechanics·Beth GalleEric Nauman
Apr 5, 2011·Biomechanics and Modeling in Mechanobiology·Spencer P LakeDawn M Elliott
Jul 5, 2011·Ophthalmology·Brian A FrancisScott D Smith
Dec 1, 2011·Molecular & Cellular Proteomics : MCP·Ronan S RogersJohn G Flanagan
Mar 6, 2012·Mechanics of Materials : an International Journal·Rafael GrytzJ Crawford Downs
Apr 10, 2012·Journal of Biomechanical Engineering·Steve A MaasJeffrey A Weiss
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Nov 29, 2012·Biomechanics and Modeling in Mechanobiology·Baptiste CoudrillierThao D Nguyen
Oct 23, 2013·Current Eye Research·David KrižajValery I Shestopalov
Dec 18, 2013·Investigative Ophthalmology & Visual Science·Ian A SigalDonald J Brown
Sep 23, 2014·Investigative Ophthalmology & Visual Science·Massimo A FazioJ Crawford Downs
Nov 13, 2014·Investigative Ophthalmology & Visual Science·Rafael GrytzJ Crawford Downs
Mar 5, 2015·Investigative Ophthalmology & Visual Science·Liang ZhangMichaël J A Girard
Mar 10, 2015·Journal of Biomechanical Engineering·Baptiste CoudrillierThao D Nguyen
Jul 22, 2015·Computer Methods in Biomechanics and Biomedical Engineering·Avinash AyyalasomayajulaJonathan P Vande Geest
Dec 30, 2015·Biomedical Optics Express·Ning-Jiun JanIan A Sigal

❮ Previous
Next ❯

Citations

Oct 30, 2018·Investigative Ophthalmology & Visual Science·Bryn L BrazileIan A Sigal
Apr 29, 2020·Investigative Ophthalmology & Visual Science·Dan MidgettThao D Nguyen
May 10, 2018·Scientific Reports·Bo WangGadi Wollstein
Sep 11, 2020·Investigative Ophthalmology & Visual Science·Yik Tung Tracy LingThao D Nguyen
Nov 10, 2020·Investigative Ophthalmology & Visual Science·Andrew P VoorheesIan A Sigal
Feb 24, 2019·Acta Biomaterialia·Reza BehkamJonathan P Vande Geest
Jul 11, 2021·Acta Biomaterialia·Alireza KarimiJ Crawford Downs

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.