PMID: 9533423Apr 9, 1998Paper

Effects of combination therapy with an angiotensin converting enzyme inhibitor and thiazide diuretic on insulin action in essential hypertension

Journal of Hypertension
S J HunterP M Bell

Abstract

To determine whether combination of an angiotensin converting enzyme inhibitor with a high dose of thiazide diuretic avoids adverse metabolic consequences of thiazide diuretics. Double-blind randomized crossover study of two 12-week treatment periods with captopril (up to 100 mg/day) either alone or in combination with 5 mg bendrofluazide given after a 6-week placebo run-in period. Treatment periods were separated by a 6-week placebo washout period. Outpatient clinics in greater Belfast. Fifteen white non-diabetic essential hypertensives (seven male) aged < 65 years recruited from general practices in greater Belfast. Systolic and diastolic blood pressures and peripheral and hepatic insulin action. Two patients failed to complete the study. Blood pressure was lowered (139/89+/-18/7 mmHg combination versus 160/97+/-21/7 mmHg captopril; P < 0.001). Fasting insulin level was raised (7.9+/-3.6 mU/l combination versus 6.2+/-3.2 mU/l baseline; P < 0.001). There were no differences between treatments for glucose, urate, cholesterol and triglyceride levels. Serum potassium level was lowered (3.8+/-0.4 mmol/l combination versus 4.2+/-0.4 mmol/l captopril, P < 0.05). Postabsorptive endogenous glucose production was raised (10.8+/-1.7 mic...Continue Reading

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Citations

Sep 25, 2003·Metabolism: Clinical and Experimental·C Hamish CourtneyPatrick M Bell
May 26, 2010·Journal of Hypertension·James R SowersPrakash C Deedwania
Apr 15, 2004·Postgraduate Medical Journal·S U ShahW A Littler
Feb 21, 2013·Hypertension·Adam Whaley-Connell, James R Sowers
Mar 8, 2006·The Canadian Journal of Cardiology·David F Blackburn, Thomas W Wilson
Apr 27, 2011·Journal of the American Academy of Nurse Practitioners·Margaret A Fitzgerald
Jul 8, 2008·The American Journal of Cardiology·C Venkata S Ram
May 18, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S M ArribasJ C McGrath
Jun 3, 2014·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Tatsuya TakahashiTeruo Tsuchiya
Apr 6, 2000·Current Opinion in Lipidology·R De Caterina
Nov 21, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·R De Caterina
Jun 29, 2000·Journal of Hypertension·M I WiggamP M Bell

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