PMID: 8603447Jan 1, 1996Paper

Effects of combined and sequential treatment with tamoxifen and the aromatase inhibitor vorozole on 7,12-dimethylbenz(a) anthracene-induced mammary carcinoma in the rat

Cancer Chemotherapy and Pharmacology
R F Van GinckelR De Coster

Abstract

The aromatase inhibitor vorozole dose-dependently inhibited the growth of dimethylbenz(a) anthracene (DMBA)-induced mammary carcinoma in the rat. An oral dose of 5 mg/kg per day brought about growth inhibition and reduction of tumor multiplicity similar to that produced by ovariectomy. Tamoxifen (8 mg/kg per day) also reduced tumor growth, albeit to a lesser extent than did ovariectomy. Concomitant administration of varying doses of tamoxifen with the fully effective dose of vorozole (5 mg/kg per day) tended to be less effective than ovariectomy of vorozole alone. This is likely to be due to the estrogen-agonistic effects of tamoxifen. Combination of tamoxifen with the partially effective dose of vorozole (1 mg/kg per day) gave results comparable with those obtained for either of the compounds used in monotherapy. Combining tamoxifen with a marginally active low dose of vorozole (0.2 mg/kg per day) resulted in a minor additional growth inhibition as compared with that obtained with this dose of vorozole alone. Sequential treatment with tamoxifen (8 mg/kg per day) for 42 days and vorozole (5 mg/kg per day) for 42 days, and vice-versa, was performed with a drug-free interval of 14 days between treatments. Tumors regressing under ...Continue Reading

Citations

Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Y TakatsukaH Maruyama
Jan 27, 1999·Journal of Pharmaceutical and Biomedical Analysis·M JimidarJ Hoogmartens
Jul 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A AwadaM J Piccart
Jun 9, 2000·Breast Cancer Research and Treatment·K ChristovR Lubet
Dec 18, 2001·The Oncologist·L B MichaudA U Buzdar
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·G ShyamalaE Dale
May 1, 1997·Cancer Treatment Reviews·W R Miller

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