PMID: 2499443Jun 1, 1989Paper

Effects of combined insulin-sulfonylurea therapy in type II patients

Diabetes Care
M S LewittM J Hooper

Abstract

We conducted a double-blind crossover study to determine which patient characteristics best predict a beneficial response to combined insulin-glyburide therapy. Glyburide (15 mg/day) or placebo was added to the treatment regimen of 31 insulin-treated type II (non-insulin-dependent) diabetic subjects. During glyburide therapy, there was a significant improvement in glycemic control with a reduction in glycosylated hemoglobin from 9.9 +/- 1.3 to 9.1 +/- 1.3% (P less than .001). Patients who responded had higher fasting C-peptide levels (P less than .001) and shorter durations of insulin therapy (P less than .01) than those who did not respond. Glyburide withdrawal was associated with a greater than expected deterioration in glycemic control. Patients on insulin therapy for greater than 8 yr are unlikely to benefit significantly from the addition of glyburide to their treatment regimen.

Citations

Apr 1, 1994·Diabetes/metabolism Reviews·A E PontiroliG Pozza
Jul 3, 1998·Diabetes Research and Clinical Practice·M N FeinglosD L Bursey
Feb 1, 1990·Australian and New Zealand Journal of Ophthalmology·C P White, M J Hooper
May 25, 2011·Expert Opinion on Drug Safety·Devindra SehraShiv Tej Sehra
Jun 23, 2009·Expert Opinion on Drug Safety·Joanna Mitri, Osama Hamdy
Apr 20, 2004·Obesity Research·Priscilla HollanderChristian Weyer
Jun 24, 1991·The American Journal of Medicine·S HalimiP Y Benhamou
May 1, 1991·Diabetes Research and Clinical Practice·H TakatsukiH Nawata
Jan 1, 1991·Diabetes Research and Clinical Practice·M C Riddle
Aug 20, 1990·The American Journal of Medicine·D C Simonson
Apr 24, 2001·Diabetes Care·H Yki-Järvinen
Jan 20, 2012·The Cochrane Database of Systematic Reviews·Sander KoningJohannes C van der Wouden
Jul 17, 2018·International Journal of Endocrinology and Metabolism·Hengameh AbdiAtieh Amouzegar

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