Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal guinea pig model

Journal of Developmental Origins of Health and Disease
A L CumberlandJonathan J Hirst

Abstract

Intrauterine growth restriction (IUGR) and maternal stress during pregnancy are two compromises that negatively impact neurodevelopment and increase the risk of developing later life neuropsychiatric disorders such as schizophrenia, depression and behavioural disorders. Neurosteroids, particularly allopregnanolone, are important in protecting the developing brain and promoting many essential neurodevelopmental processes. Individually, IUGR and prenatal stress (PS) reduce myelination and neurogenesis within affected fetal brains, however less information is available on the combined effects of these two disorders on the term fetal brain. This study aimed to investigate how IUGR and PS impairs the neurosteroid pathway when combined using a guinea pig model, and how these then disrupt the neurodevelopment of the fetus. Uterine artery blood flow restriction was performed at GA30-35 to induce growth restriction, whilst PS was induced by exposure of the dam to a strobe light during gestation commencing GA40 and repeated every 5 days. Exposure in this model caused reductions in hippocampal CA1 MBP immunostaining of male fetuses in both IUGR alone and IUGR+PS paradigms but only by IUGR in the subcortical white mater, compared with cont...Continue Reading

References

Mar 1, 1977·British Journal of Obstetrics and Gynaecology·S Campbell, A Thoms
Aug 1, 1992·The American Journal of Psychiatry·W G Iacono, M Beiser
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·I Nitsos, S Rees
Jan 6, 1970·Brain Research·J Dobbing, J Sands
Aug 26, 1998·The British Journal of Psychiatry : the Journal of Mental Science·J van Os, J P Selten
Oct 26, 1999·Development and Psychopathology·J B WatsonX Wang
Mar 10, 2000·Pediatric Research·S G Matthews
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·V LemaireD N Abrous
Oct 9, 2002·JAMA : the Journal of the American Medical Association·F Xavier CastellanosJudith L Rapoport
Feb 28, 2003·Journal of Neurobiology·Sandra Dieni, Sandra Rees
Jun 11, 2003·Archives of General Psychiatry·Andre AlemanJean-Paul Selten
Oct 29, 2003·Early Human Development·Carolina de WeerthJan K Buitelaar
Nov 20, 2003·Biological Psychiatry·Christopher L CoeEberhard Fuchs
Apr 16, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Greg D GaleMichael S Fanselow
Aug 28, 2004·The Journal of Physiology·Phuong N NguyenJonathan J Hirst
Apr 7, 2005·Neuroscience and Biobehavioral Reviews·Bea R H Van den BerghLieven Lagae
Jun 17, 2005·Nature Reviews. Neuroscience·Delia Belelli, Jeremy J Lambert
Sep 1, 2005·Journal of Autism and Developmental Disorders·D Q BeversdorfM L Bauman
Oct 29, 2005·Journal of Neuropathology and Experimental Neurology·Paul OlivierCatherine Verney
Dec 24, 2005·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Susan E Gilbert EvansMyroslava K Romach
Jan 20, 2006·The European Journal of Neuroscience·Maria Xilouri, Panagiota Papazafiri
Aug 10, 2006·Stress : the International Journal on the Biology of Stress·Michał KraszpulskiA K Salm
Aug 29, 2006·Biological Psychiatry·Ann M RasmussonAlessandro Guidotti
Feb 24, 2007·Neurobiology of Disease·Paul OlivierCatherine Verney
May 25, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E TidemanD Ley
Dec 1, 2007·Journal of the American Academy of Child and Adolescent Psychiatry·Kristin BergmanVivette Glover

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