Effects of combined maternal administration with alpha-ketoglutarate (AKG) and β-hydroxy-β-methylbutyrate (HMB) on prenatal programming of skeletal properties in the offspring.

Nutrition & Metabolism
Marcin TataraT Studziński

Abstract

Nutritional manipulations during fetal growth may induce long-term metabolic effects in postnatal life. The aim of the study was to test whether combined treatment of pregnant sows with alpha-ketoglutarate and β-hydroxy-β-methylbutyrate induces additive long-term effects on skeletal system properties in the offspring. The study was performed on 290 pigs obtained from 24 sows divided into 4 equal groups and subjected to experimental treatment during two weeks before delivery. The first group consisted of control sows, while the second group received alpha-ketoglutarate. The third group was treated with β-hydroxy-β-methylbutyrate and the fourth group underwent combined administration of alpha-ketoglutarate and β-hydroxy-β-methylbutyrate. Piglets obtained from sows were reared until slaughter age to perform morphometric, densitometric and mechanical analyses of femur. Serum evaluations of growth hormone, insulin-like growth factor-1, bone-specific alkaline phosphatase and osteocalcin were performed in newborns and 90-day old piglets; additionally, plasma amino acid concentration was measured in newborns. Maternal treatment with alpha-ketoglutarate and β-hydroxy-β-methylbutyrate significantly reduced fattening time and increased bi...Continue Reading

References

Feb 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B StollD Häussinger
May 1, 1990·Metabolism: Clinical and Experimental·S A BrownW Patsch
Nov 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J L FerrettiJ R Zanchetta
Jan 1, 1997·Annals of the Rheumatic Diseases·C CooperD Barker
Jan 22, 1998·The Journal of Clinical Endocrinology and Metabolism·C FallC Cooper
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·K SjögrenC Ohlsson
Dec 1, 1999·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M Jeevanandam, S R Petersen
Feb 15, 2001·Placenta·F C Battaglia, T R Regnault
Mar 10, 2001·Journal of Molecular Endocrinology·R RizzoliS L Ferrari
Apr 18, 2002·Calcified Tissue International·Richard Eastell, Helen Lambert
Apr 18, 2002·Calcified Tissue International·C CooperN Arden
Aug 23, 2002·Annals of Surgery·Jeremy Z WilliamsAdrian Barbul
Feb 28, 2003·Clinical Science·U B FläringF Hammarqvist
Mar 29, 2003·Mechanisms of Ageing and Development·José Luis FerrettiHarold M Frost
Apr 3, 2004·Seminars in Perinatology·Susan E OzanneC Nicholas Hales
May 7, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·A L Fowden, A J Forhead
Dec 14, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael G Ross, Mina Desai
Aug 9, 2005·Early Human Development·Abigail L FowdenAlison J Forhead
Jan 10, 2006·Lancet·M K JavaidUNKNOWN Princess Anne Hospital Study Group
Apr 15, 2006·Journal of Applied Physiology·Stuart J Warden
Aug 5, 2006·Early Human Development·Hans DemmelmairBerthold Koletzko
Nov 18, 2008·Journal of Animal Physiology and Animal Nutrition·N K AndersenA P Harrison
Mar 21, 2009·Amino Acids·Guoyao Wu
May 22, 2010·Journal of Animal Physiology and Animal Nutrition·E Śliwa
Jan 18, 2011·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·F Gerlinger-RomeroM T Nunes

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Citations

Feb 5, 2013·Journal of the International Society of Sports Nutrition·Jacob M WilsonJose Antonio
Aug 8, 2014·Journal of Animal Physiology and Animal Nutrition·K A SzcześniakT Sadkowski
Jun 22, 2016·Archivum Immunologiae Et Therapiae Experimentalis·Barbara ZdzisińskaMartyna Kandefer-Szerszeń
Apr 24, 2016·Molecular Aspects of Medicine·Thomas BriocheAngèle Chopard

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Methods Mentioned

BETA
ELISA
Assay
ion-exchange chromatography

Software Mentioned

MIKRO
Microplate Manager

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