Effects of combined stretching and clenbuterol on disuse atrophy in rat soleus muscle

Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō
Toshiaki YamazakiK Tachino

Abstract

Clinically, disuse muscle atrophy is often seen among patients who are severely debilited and are on prolonged bed rest. Common physical therapy interventions are not successful in preventing disuse muscle atrophy early in the medical treatment of critically ill patients. In situations such as this, the use of a β 2-adrenergic agonist such as clenbuterol (Cb) may be of benefit in preventing atrophy. Also, recent studies have suggested that stretching is possible in preventing disuse muscle atrophy and the decline in muscle strength. The objective of this study was to evaluate the effects of Cb medication combined with stretching (ST) on rat soleus muscle (SOL) during the progression of disuse muscle atrophy. Thirty-five male Wistar rats were used in this study. The rats were divided into five groups: control (CON), hindlimb-unweighting (HU) only, HU+ST, HU+Cb medication, and HU+ST+Cb groups. The right SOL in stretching groups was maintained a stretched position for one hour daily by passively dorsiflexing the ankle joint under non-anesthesia. The experimental period was 2 weeks. In the ST group, peak twitch tension per cross-sectional area in soleus muscle was significantly larger than in the Cb group, while there was no signif...Continue Reading

References

Oct 1, 1992·Journal of the American Geriatrics Society·M J GorbienL Z Rubenstein
Jun 1, 1988·The American Journal of Physiology·R J ZemanJ D Etlinger
Jun 1, 1995·Archives of Physical Medicine and Rehabilitation·M Brown, E M Hasser
Mar 11, 2000·American Journal of Physiology. Cell Physiology·C Ricart-FiringaY Mounier
Oct 13, 2000·American Journal of Physiology. Cell Physiology·L StevensD Pette
Jul 7, 2001·Archives of Physical Medicine and Rehabilitation·N M HerreraL V Thompson
Dec 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·Bonaventure L AwedeJean Lebacq
Jul 5, 2002·Cells, Tissues, Organs·Lawrence E WineskiDouglas F Paulsen
Sep 17, 2002·The Japanese Journal of Physiology·Motoko OhiraYoshinobu Ohira
Sep 28, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A R S GomesT F Salvini
Nov 24, 2004·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E L CoutinhoT F Salvini
Jan 1, 1998·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·T YamazakiK Tachino
Jan 1, 2001·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·T YamazakiK Tachino
Jan 1, 2003·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Toshiaki Yamazaki
Jan 1, 2005·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Toshiaki Yamazaki

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.