Effects of combined therapy with clopidogrel and acetylsalicylic acid on platelet glycoprotein expression and aggregation

Journal of Cardiovascular Pharmacology
Gesine DörrEckart Fleck

Abstract

This study aimed to compare the effects of clopidogrel, acetylsalicylic acid (ASA), and the combination of both substances on platelet aggregation and expression of platelet membrane glycoproteins in patients with chronic coronary artery disease. We investigated platelet activation by flow cytometry and by platelet aggregation and disaggregation in 60 patients randomly assigned to 3 treatment groups: ASA, clopidogrel, combination of clopidogrel and ASA, treated for 14 days. Adenosine diphosphate (ADP)-induced expression of P-selectin and of PAC-1 was significantly reduced after 2 wk of clopidogrel but not of ASA treatment. Treatment with clopidogrel reduced the ADP-induced platelet aggregation. The combination of clopidogrel and ASA did not increase the inhibition of platelet activation compared with clopidogrel alone. A significant increase in platelet disaggregation was observed with clopidogrel alone and was more pronounced with the combination of clopidogrel and ASA. ADP-induced platelet degranulation, activation of GPIIb/IIIa receptor, and aggregation in vivo are effectively inhibited by clopidogrel. The significantly increased disaggregation under clopidogrel and ASA suggests that the combined therapy may be superior to t...Continue Reading

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Citations

Jan 16, 2008·CNS Drugs·Matthias W Riepe, Roman Huber
May 8, 2013·Indian Heart Journal·Kavita K ShaliaSatchidanand Payannavar
Jan 24, 2007·Journal of Thrombosis and Haemostasis : JTH·G VilahurJ J Badimon
Feb 26, 2004·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Jonathan D SmoutGerard Stansby
Oct 13, 2009·The Cochrane Database of Systematic Reviews·Cathie Lm SudlowGraeme J Hankey
Jun 25, 2008·Journal of Cardiovascular Pharmacology·Thomas WalterHans Martin Hoffmeister

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