Effects of combining extracts (from propolis or Zingiber officinale) with clarithromycin on Helicobacter pylori

Phytotherapy Research : PTR
A NostroV Alonzo

Abstract

Propolis and Zingiber officinale have been shown to be specifically targeted against Helicobacter pylori strains, to possess antiinflammatory, antioxidant and antitumoral activity and to be used in traditional medicine for the treatment of gastrointestinal ailments. Considering that these natural products could potentially serve as novel therapeutic tools also in combination with an antibiotic, the aim of this work was to evaluate their effect when combined with clarithromycin on clinical H. pylori isolates (n = 25), characterized in respect to both clarithromycin susceptibility and the presence of the cagA gene. The results showed that the combinations of propolis extract + clarithromycin and Z. officinale extract + clarithromycin exhibited improved inhibition of H. pylori with synergistic or additive activity. Interestingly, the susceptibility to combinations was significantly independent of the microbial clarithromycin susceptibility status. Only one H. pylori strain showed antagonism towards the Z. officinale extract + clarithromycin combination. The data demonstrate that combinations of propolis extract + clarithromycin and Z. officinale extract + clarithromycin have the potential to help control H. pylori-associated gastr...Continue Reading

References

Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Nov 1, 1985·Journal of Ethnopharmacology·H HikinoT Namiki
Jan 25, 1997·Lancet·C S GoodwinT C Northfield
Jul 3, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·G A Burdock
May 7, 1999·The American Journal of Medicine·J M Scheiman, A F Cutler
Dec 21, 2000·Alimentary Pharmacology & Therapeutics·S ToracchioL Marzio
Apr 9, 2001·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·A H BanskotaS Kadota
Dec 18, 2001·Journal of Pharmaceutical Sciences·S BhattaraiC C Duke
Apr 12, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Ana Paula BazoDaisy Maria Fávero Salvadori
Sep 17, 2002·The American Journal of Chinese Medicine·Chi-Feng LiuSong-Chow Lin
Mar 13, 2003·East African Medical Journal·J F T K AkoachereD N Anong
May 3, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·L MarzioD Angelucci
Jan 14, 2004·Microbiological Research·Srdjan StepanovićMilena Svabić-Vlahović
Feb 11, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S ToracchioL Marzio
Jun 4, 2005·Phytotherapy Research : PTR·A NostroV Alonzo

❮ Previous
Next ❯

Citations

Sep 21, 2013·Parasitology Research·Eman K A Bazh, Nasr M El-Bahy
Aug 19, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Jang-Gi ChoiDong-Yeul Kwon
Feb 28, 2007·Journal of Ethnobiology and Ethnomedicine·Cheryl LansWilli Boepple
Oct 23, 2013·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Raju Senthil KumarThambidurai Punitha
Oct 6, 2007·Scandinavian Journal of Gastroenterology·Luigina CelliniRoberto Lattanzio
Aug 15, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Robert D WojtyczkaTomasz J Wąsik
Sep 1, 2007·Helicobacter·Luiz Gonzaga Vaz CoelhoOsmar Reni Trindade
Sep 9, 2015·International Journal of Dentistry·Arash AziziShirin Lawaf
May 25, 2016·International Journal of Antimicrobial Agents·Francesca SistoDonatella Taramelli
Jul 16, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Satendra Kumar Nirala, Monika Bhadauria
Apr 2, 2015·Brazilian Dental Journal·Lilian Eiko MaekawaMarcia Carneiro Valera
Jun 1, 2010·Midwives·Denise Tiran
Aug 19, 2014·World Journal of Gastroenterology : WJG·Yuan-Chuen Wang
Aug 6, 2019·Advanced Pharmaceutical Bulletin·Vahideh Ebrahimzadeh AttariNeda Lotfi
Mar 7, 2014·Letters in Applied Microbiology·L CelliniM Di Giulio
Sep 24, 2010·Journal of Pediatric Orthopedics. Part B·Mithat OnerMahmut Argun
May 29, 2020·Toxicology Reports·Anis Yohana ChaerunisaaAnas Subarnas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.