Effects of comorbid anxiety disorders on the longitudinal course of pediatric bipolar disorders.

Journal of the American Academy of Child and Adolescent Psychiatry
Regina SalaBoris Birmaher

Abstract

To examine the longitudinal effects of comorbid anxiety disorders in youth with bipolar spectrum disorder (BP). As part of the Course and Outcome of Bipolar Youth study, 413 youth, who were 7 through 17 years or age and who met criteria for DSM-IV BP-I (n = 244), BP-II (n = 28), and operationally defined bipolar disorder not otherwise specified (BP-NOS) (n = 141) were included. Subjects were followed on average 5 years using the Longitudinal Interval Follow-up Evaluation. Effects of anxiety on the time to mood recovery and recurrence and percentage of time with syndromal and subsyndromal mood symptomatology during the follow-up period were analyzed. At intake and during the follow-up, 62% of youth with BP met criteria for at least 1 anxiety disorder. About 50% of the BP youth with anxiety had ≥2 anxiety disorders. Compared to BP youth without anxiety, those with anxiety had significantly more depressive recurrences and significantly longer median time to recovery. The effects of anxiety on recovery disappeared when the severity of depression at intake was taken into account. After adjusting for confounding factors, BP youth with anxiety, particularly those with ≥2 anxiety disorders, spent significantly less follow-up time asymp...Continue Reading

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Citations

Feb 16, 2016·The Psychiatric Clinics of North America·Fernando S Goes
Oct 18, 2015·Acta Psychiatrica Scandinavica·S YenM B Keller
Aug 25, 2015·Journal of the American Academy of Child and Adolescent Psychiatry·Manpreet K SinghIan H Gotlib
Dec 30, 2014·Journal of Affective Disorders·Álvaro FríasNúria Farriols
Apr 12, 2017·Journal of Child and Adolescent Psychopharmacology·Rasim Somer DilerBoris Birmaher
Jan 4, 2019·Journal of Affective Disorders·Heather HowerShirley Yen
Jan 10, 2019·Journal of Affective Disorders·Marc J WeintraubDavid J Miklowitz
Jan 20, 2021·Journal of Child and Adolescent Psychopharmacology·Matthew SanchezMolly McVoy

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