Effects of Comorbid Depression and Diabetes Mellitus on Cognitive Decline in Older Mexican Americans

Journal of the American Geriatrics Society
Brian DownerKyriakos Markides

Abstract

To assess the relationship between comorbid depression, diabetes mellitus (DM), and cognitive decline in Mexican Americans aged 65 and older. Retrospective cohort study with longitudinal analysis. Texas, New Mexico, Colorado, Arizona, and California. Hispanic Established Populations for the Epidemiologic Study of the Elderly. Cognition was assessed using the Mini-Mental State Examination (MMSE). Depression was defined as a score of 16 or greater on the Center for Epidemiologic Studies Depression Scale. DM was defined as according to self-reported history or taking insulin or oral hypoglycemic medication. Participants with depression and DM declined an average of 6.5 points on the MMSE; depression only, 4.4 points; DM only, 7.8 points; and neither condition, 4.2 points across the six examination waves. Participants with DM declined an average of 0.18 more points on the MMSE per year (P = .001) than those with neither DM nor depression, and those with comorbid DM and depression declined 0.25 more points per year (P = .002). Depression was associated with significantly greater cognitive decline (β^ = -0.11, P = .05) after excluding participants with baseline cognitive impairment (MMSE score ≤17). Participants with DM were 1.08 (95...Continue Reading

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Citations

Nov 10, 2018·The Physician and Sportsmedicine·Paul D LoprinziKatherine L Tucker
Jun 21, 2017·International Psychogeriatrics·Leigh A JohnsonSid E O'Bryant
Oct 2, 2020·Asia-Pacific Journal of Public Health·Jongnam HwangSujin Kim
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Apr 14, 2021·Journal of Aging and Health·Man GuoXinQi Dong

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